Engraftment of Insulin-producing Cells from Porcine Islets in Non-immune-suppressed Rats or Nonhuman Primates Transplanted Previously with Embryonic Pig Pancreas

Overview

Journal J Transplant

Publisher Wiley

Specialty General Surgery

Date 2011 Oct 5

PMID 21969909

Citations 1

Authors

Marc R Hammerman

Affiliations

Soon will be listed here.

Abstract

Transplantation therapy for diabetes is limited by unavailability of donor organs and outcomes complicated by immunosuppressive drug toxicity. Xenotransplantation is a strategy to overcome supply problems. Implantation of tissue obtained early during embryogenesis is a way to reduce transplant immunogenicity. Insulin-producing cells originating from embryonic pig pancreas obtained very early following pancreatic primordium formation (embryonic day 28 (E28)) engraft long-term in non-immune, suppressed diabetic rats or rhesus macaques. Morphologically, similar cells originating from adult porcine islets of Langerhans (islets) engraft in non-immune-suppressed rats or rhesus macaques previously transplanted with E28 pig pancreatic primordia. Our data are consistent with induction of tolerance to an endocrine cell component of porcine islets induced by previous transplantation of embryonic pig pancreas, a novel finding we designate organogenetic tolerance. The potential exists for its use to enable the use of pigs as islet cell donors for humans with no immune suppression requirement.

Citing Articles

Development of a novel xenotransplantation strategy for treatment of diabetes mellitus in rat hosts and translation to non-human primates.

Hammerman M Organogenesis. 2012; 8(2):41-8.

PMID: 22699748 PMC: 3429511. DOI: 10.4161/org.20930.

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