Endocrine Self and Gut Non-self Intersect in the Pancreatic Lymph Nodes

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2005 Dec 1

PMID 16317068

Citations 97

Authors

Shannon J Turley

Je-Wook Lee

Nick Dutton-Swain

Diane Mathis

Christophe Benoist

Affiliations

Soon will be listed here.

Abstract

The autoimmune cascade that culminates in diabetes initiates within pancreatic lymph nodes (PLNs). Here, we show that developmentally controlled lymphogenesis establishes a preferential trafficking route from the gut to the PLN, where T cells can be activated by antigens drained from the peritoneum and the gastrointestinal tract. Furthermore, intestinal stress modifies the presentation of pancreatic self-antigens in PLNs. The convergence of endocrine and intestinal contents within PLNs has significant implications for type 1 diabetes and may help to explain the link between autoimmune pathogenesis and environmental provocation.

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