Insight into the Heterogeneity of Breast Cancer Through Next-generation Sequencing

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2011 Oct 4

PMID 21965338

Citations 119

Authors

Hege G Russnes

Nicholas Navin

James Hicks

Anne-Lise Borresen-Dale

Affiliations

Soon will be listed here.

Abstract

Rapid and sophisticated improvements in molecular analysis have allowed us to sequence whole human genomes as well as cancer genomes, and the findings suggest that we may be approaching the ability to individualize the diagnosis and treatment of cancer. This paradigmatic shift in approach will require clinicians and researchers to overcome several challenges including the huge spectrum of tumor types within a given cancer, as well as the cell-to-cell variations observed within tumors. This review discusses how next-generation sequencing of breast cancer genomes already reveals insight into tumor heterogeneity and how it can contribute to future breast cancer classification and management.

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