Prevalence of Sleep Disturbances in Children and Adolescents with Chronic Kidney Disease

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 2011 Oct 4

PMID 21964556

Citations 21

Authors

Ira D Davis

Larry A Greenbaum

Debbie Gipson

Lie Ling Wu

Rajiv Sinha

Mina Matsuda-Abedini

Judith L Emancipator

Jerome C Lane

Kavita Hodgkins

Corina Nailescu

Gina Marie Barletta

Steven Arora

John D Mahan

Carol L Rosen

Affiliations

Soon will be listed here.

Abstract

Although sleep disorders are common in adults with chronic kidney disease, little is known about the prevalence of sleep problems in children and adolescents with chronic kidney disease and their relationship to health-related quality of life measurements. We performed a clinic-based survey of sleep habits and common symptoms of sleep disturbances in 159 school-aged patients with chronic kidney disease. Three patient groups of chronic kidney disease were assessed: group 1, those not on dialysis and not transplanted; group 2, those on dialysis; and group 3, those with a functioning renal allograft. Four symptom domains for sleep disorders were assessed: excessive daytime sleepiness; sleep disordered breathing; restless legs syndrome symptoms; and insufficient sleep. Patients and the parent-proxy also completed the Pediatric Quality of Life Inventory Version 4.0 Generic Core Scales questionnaire. Ninety-three (93) patients (58.5%) had symptoms of a sleep disturbance. The presence of a sleep disturbance correlated with a decrease in health-related quality of life scores that was independent of the chronic kidney disease study group or estimated glomerular filtration rate. We conclude that sleep disturbances are common throughout the spectrum of chronic kidney disease in children and adolescents and are associated with diminished health-related quality of life scores.

Citing Articles

The Effect of Sleep Habits on Quality of Life in Pediatric Patients With Chronic Kidney Disease.

Taner S, Ekberli G, Gunes S Cureus. 2024; 16(7):e64585.

PMID: 39144881 PMC: 11324010. DOI: 10.7759/cureus.64585.

A systematic review of symptoms experienced by children and young people with kidney failure.

Jacob Z, Plumb L, Oni L, Mitra S, Reynolds B Pediatr Nephrol. 2024; 40(1):53-68.

PMID: 39095515 DOI: 10.1007/s00467-024-06465-8.

The Sleep Patterns of Children and Adolescents with Chronic Conditions and Their Families: An Integrative Literature Review.

Xavier W, Abreu M, Nunes M, Silva-Rodrigues F, Silva L, de Araujo B Children (Basel). 2024; 11(2).

PMID: 38397320 PMC: 10887388. DOI: 10.3390/children11020207.

Sleep disturbances in children and adolescents after kidney transplantation.

Yang M, Chuang S, Kennedy S Pediatr Nephrol. 2023; 39(5):1577-1585.

PMID: 38082092 DOI: 10.1007/s00467-023-06204-5.

Restless Legs Syndrome in Chronic Kidney Disease- a Systematic Review.

Safarpour Y, Vaziri N, Jabbari B Tremor Other Hyperkinet Mov (N Y). 2023; 13:10.

PMID: 37008995 PMC: 10064886. DOI: 10.5334/tohm.752.

References

Tang S, Lam B, Yao T, Leung W, Chu C, Ho Y . Sleep apnea is a novel risk predictor of cardiovascular morbidity and death in patients receiving peritoneal dialysis. Kidney Int. 2010; 77(11):1031-8. DOI: 10.1038/ki.2010.76. View

Parker K . Sleep disturbances in dialysis patients. Sleep Med Rev. 2003; 7(2):131-43. DOI: 10.1053/smrv.2001.0240. View

Roumelioti M, Wentz A, Schneider M, Gerson A, Hooper S, Benfield M . Sleep and fatigue symptoms in children and adolescents with CKD: a cross-sectional analysis from the chronic kidney disease in children (CKiD) study. Am J Kidney Dis. 2009; 55(2):269-80. PMC: 2814922. DOI: 10.1053/j.ajkd.2009.09.021. View

Ievers-Landis C, Redline S . Pediatric sleep apnea: implications of the epidemic of childhood overweight. Am J Respir Crit Care Med. 2006; 175(5):436-41. PMC: 2176093. DOI: 10.1164/rccm.200606-790PP. View

Ogden C, Kuczmarski R, Flegal K, Mei Z, Guo S, Wei R . Centers for Disease Control and Prevention 2000 growth charts for the United States: improvements to the 1977 National Center for Health Statistics version. Pediatrics. 2002; 109(1):45-60. DOI: 10.1542/peds.109.1.45. View

Heath J, Mackinlay D, Watson A, Hames A, Wirz L, Scott S . Self-reported quality of life in children and young people with chronic kidney disease. Pediatr Nephrol. 2011; 26(5):767-73. DOI: 10.1007/s00467-011-1784-2. View

Varni J, Seid M, Kurtin P . PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. Med Care. 2001; 39(8):800-12. DOI: 10.1097/00005650-200108000-00006. View

Chervin , Hedger , Dillon , Pituch . Pediatric sleep questionnaire (PSQ): validity and reliability of scales for sleep-disordered breathing, snoring, sleepiness, and behavioral problems. Sleep Med. 2000; 1(1):21-32. DOI: 10.1016/s1389-9457(99)00009-x. View

Iliescu E, Yeates K, Holland D . Quality of sleep in patients with chronic kidney disease. Nephrol Dial Transplant. 2003; 19(1):95-9. DOI: 10.1093/ndt/gfg423. View

10.

Rosen C, Palermo T, Larkin E, Redline S . Health-related quality of life and sleep-disordered breathing in children. Sleep. 2002; 25(6):657-66. View

11.

Rosen C, Larkin E, Kirchner H, Emancipator J, Bivins S, Surovec S . Prevalence and risk factors for sleep-disordered breathing in 8- to 11-year-old children: association with race and prematurity. J Pediatr. 2003; 142(4):383-9. DOI: 10.1067/mpd.2003.28. View

12.

Kutner N, Zhang R, Huang Y, Bliwise D . Association of sleep difficulty with Kidney Disease Quality of Life cognitive function score reported by patients who recently started dialysis. Clin J Am Soc Nephrol. 2007; 2(2):284-9. DOI: 10.2215/CJN.03000906. View

13.

Winkelman J, Redline S, Baldwin C, Resnick H, Newman A, Gottlieb D . Polysomnographic and health-related quality of life correlates of restless legs syndrome in the Sleep Heart Health Study. Sleep. 2009; 32(6):772-8. PMC: 2690565. DOI: 10.1093/sleep/32.6.772. View

14.

Novak M, Molnar M, Ambrus C, Kovacs A, Koczy A, Remport A . Chronic insomnia in kidney transplant recipients. Am J Kidney Dis. 2006; 47(4):655-65. DOI: 10.1053/j.ajkd.2005.12.035. View

15.

Allen R, Picchietti D, Hening W, Trenkwalder C, Walters A, Montplaisi J . Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003; 4(2):101-19. DOI: 10.1016/s1389-9457(03)00010-8. View

16.

Marin J, Carrizo S, Vicente E, Agusti A . Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet. 2005; 365(9464):1046-53. DOI: 10.1016/S0140-6736(05)71141-7. View

17.

Merlino G, Piani A, Dolso P, Adorati M, Cancelli I, Valente M . Sleep disorders in patients with end-stage renal disease undergoing dialysis therapy. Nephrol Dial Transplant. 2005; 21(1):184-90. DOI: 10.1093/ndt/gfi144. View

18.

Elder S, Pisoni R, Akizawa T, Fissell R, Andreucci V, Fukuhara S . Sleep quality predicts quality of life and mortality risk in haemodialysis patients: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant. 2007; 23(3):998-1004. DOI: 10.1093/ndt/gfm630. View

19.

Jung H, Han H, Lee J . Sleep apnea, coronary artery disease, and antioxidant status in hemodialysis patients. Am J Kidney Dis. 2005; 45(5):875-82. DOI: 10.1053/j.ajkd.2005.01.006. View

20.

Mallon L, Broman J, Hetta J . Restless legs symptoms with sleepiness in relation to mortality: 20-year follow-up study of a middle-aged Swedish population. Psychiatry Clin Neurosci. 2008; 62(4):457-63. DOI: 10.1111/j.1440-1819.2008.01831.x. View