Sleep Disorders in Children with Chronic Kidney Disease

Overview

Journal Int J Pediatr Adolesc Med

Date 2019 Feb 27

PMID 30805480

Citations 10

Authors

Amira H Darwish

Hend Abdel-Nabi

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: This case-control study assessed the prevalence of sleep disorders among Egyptian children with chronic kidney disease (CKD), either maintained or not maintained on hemodialysis (HD), and compared them with healthy age and sex-matched children.

Patients And Methods: The total study population included 95 children, 54 of whom were CKD patients, 22 maintained on HD and 32 not maintained on HD; 41 healthy children of matched age and sex composed the control group.Subjective impairment of sleep quality was assessed using the Arabic version of the Children's Sleep Habits Questionnaire (CSHQ). Daytime sleepiness and restless leg syndrome (RLS) were assessed using a pediatric modification of the Epworth sleepiness scale (ESS) and RLS Questionnaire, respectively.

Results: Sleep disturbances were detected in 75.9% of the studied children with CKD: 81.8% in children with CKD undergoing dialysis, and 71.8% in children with CKD not on dialysis. Excessive daytime sleepiness (EDS) and RLS symptoms were reported in 22% and 20.4% of the studied children with CKD, respectively.

Conclusions: Sleep disturbances are very common among children with CKD. Sleep disturbances in patients with CKD include restless legs syndrome (RLS), excessive daytime sleepiness (EDS), sleep-disordered breathing (SDB), behavioral insomnias, and parasomnias.

Citing Articles

A systematic review of symptoms experienced by children and young people with kidney failure.

Jacob Z, Plumb L, Oni L, Mitra S, Reynolds B Pediatr Nephrol. 2024; 40(1):53-68.

PMID: 39095515 DOI: 10.1007/s00467-024-06465-8.

Association between Chronic kidney disease and restless leg syndrome (RLS): a systematic review and meta-analysis.

Aini N, Marta O, Mashfufa E, Setyowati L Sleep Biol Rhythms. 2024; 22(2):227-237.

PMID: 38524160 PMC: 10959887. DOI: 10.1007/s41105-024-00513-4.

Restless Legs Syndrome in Chronic Kidney Disease- a Systematic Review.

Safarpour Y, Vaziri N, Jabbari B Tremor Other Hyperkinet Mov (N Y). 2023; 13:10.

PMID: 37008995 PMC: 10064886. DOI: 10.5334/tohm.752.

Prevalence and Correlates of Sleep Disorders Among Pediatric Inpatients in a Tertiary Pediatric Hospital.

Alfakeh S, Mandili R, Aljabri R, Salaam S, Hamad R, Alhazmi H Cureus. 2023; 15(2):e34871.

PMID: 36923188 PMC: 10010750. DOI: 10.7759/cureus.34871.

Patient-Reported Outcomes Over 24 Months in Pediatric CKD: Findings From the MyKidneyHealth Cohort Study.

Amaral S, Schuchard J, Claes D, Dart A, Greenbaum L, Massengill S Am J Kidney Dis. 2023; 82(2):213-224.e1.

PMID: 36889426 PMC: 10440290. DOI: 10.1053/j.ajkd.2022.12.014.

References

Owens J, Spirito A, McGuinn M . The Children's Sleep Habits Questionnaire (CSHQ): psychometric properties of a survey instrument for school-aged children. Sleep. 2001; 23(8):1043-51. View

. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002; 39(2 Suppl 1):S1-266. View

Unruh M, Hartunian M, Chapman M, Jaber B . Sleep quality and clinical correlates in patients on maintenance dialysis. Clin Nephrol. 2003; 59(4):280-8. DOI: 10.5414/cnp59280. View

Allen R, Picchietti D, Hening W, Trenkwalder C, Walters A, Montplaisi J . Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003; 4(2):101-19. DOI: 10.1016/s1389-9457(03)00010-8. View

Iliescu E, Yeates K, Holland D . Quality of sleep in patients with chronic kidney disease. Nephrol Dial Transplant. 2003; 19(1):95-9. DOI: 10.1093/ndt/gfg423. View

Kavanagh D, Siddiqui S, Geddes C . Restless legs syndrome in patients on dialysis. Am J Kidney Dis. 2004; 43(5):763-71. DOI: 10.1053/j.ajkd.2004.01.007. View

Gigli G, Adorati M, Dolso P, Piani A, Valente M, Brotini S . Restless legs syndrome in end-stage renal disease. Sleep Med. 2004; 5(3):309-15. DOI: 10.1016/j.sleep.2004.01.014. View

Melendres M, Lutz J, Rubin E, Marcus C . Daytime sleepiness and hyperactivity in children with suspected sleep-disordered breathing. Pediatrics. 2004; 114(3):768-75. DOI: 10.1542/peds.2004-0730. View

Davis I, Baron J, ORiordan M, Rosen C . Sleep disturbances in pediatric dialysis patients. Pediatr Nephrol. 2004; 20(1):69-75. DOI: 10.1007/s00467-004-1700-0. View

10.

Rijsman R, de Weerd A, Stam C, Kerkhof G, Rosman J . Periodic limb movement disorder and restless legs syndrome in dialysis patients. Nephrology (Carlton). 2005; 9(6):353-61. DOI: 10.1111/j.1440-1797.2004.00330.x. View

11.

Merlino G, Piani A, Dolso P, Adorati M, Cancelli I, Valente M . Sleep disorders in patients with end-stage renal disease undergoing dialysis therapy. Nephrol Dial Transplant. 2005; 21(1):184-90. DOI: 10.1093/ndt/gfi144. View

12.

Roger S, Harris D, Stewart J . Possible relation between restless legs and anaemia in renal dialysis patients. Lancet. 1991; 337(8756):1551. DOI: 10.1016/0140-6736(91)93248-8. View

13.

De Santo R, Bartiromo M, Cesare C, Cirillo M . Sleep disorders occur very early in chronic kidney disease. J Nephrol. 2008; 21 Suppl 13:S59-65. View

14.

Goodlin-Jones B, Sitnick S, Tang K, Liu J, Anders T . The Children's Sleep Habits Questionnaire in toddlers and preschool children. J Dev Behav Pediatr. 2008; 29(2):82-88. DOI: 10.1097/dbp.0b013e318163c39a. View

15.

Applebee G, Guillot A, Schuman C, Teddy S, Attarian H . Restless legs syndrome in pediatric patients with chronic kidney disease. Pediatr Nephrol. 2008; 24(3):545-8. DOI: 10.1007/s00467-008-1057-x. View

16.

Schwartz G, Munoz A, Schneider M, Mak R, Kaskel F, Warady B . New equations to estimate GFR in children with CKD. J Am Soc Nephrol. 2009; 20(3):629-37. PMC: 2653687. DOI: 10.1681/ASN.2008030287. View

17.

Sinha R, Davis I, Matsuda-Abedini M . Sleep disturbances in children and adolescents with non-dialysis-dependent chronic kidney disease. Arch Pediatr Adolesc Med. 2009; 163(9):850-5. DOI: 10.1001/archpediatrics.2009.149. View

18.

Koch B, van der Putten K, van Someren E, Wielders J, Ter Wee P, Nagtegaal J . Impairment of endogenous melatonin rhythm is related to the degree of chronic kidney disease (CREAM study). Nephrol Dial Transplant. 2009; 25(2):513-9. DOI: 10.1093/ndt/gfp493. View

19.

Roumelioti M, Wentz A, Schneider M, Gerson A, Hooper S, Benfield M . Sleep and fatigue symptoms in children and adolescents with CKD: a cross-sectional analysis from the chronic kidney disease in children (CKiD) study. Am J Kidney Dis. 2009; 55(2):269-80. PMC: 2814922. DOI: 10.1053/j.ajkd.2009.09.021. View

20.

Roumelioti M, Argyropoulos C, Buysse D, Nayar H, Weisbord S, Unruh M . Sleep quality, mood, alertness and their variability in CKD and ESRD. Nephron Clin Pract. 2010; 114(4):c277-87. PMC: 2865402. DOI: 10.1159/000276580. View