Discovering Pluripotency: 30 Years of Mouse Embryonic Stem Cells

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2011 Sep 24

PMID 21941277

Citations 64

Authors

Martin Evans

Affiliations

Soon will be listed here.

Abstract

Embryonic stem (ES) cells are pluripotent cells isolated from an early embryo and grown as a cell line in tissue culture. Their discovery came from the conjunction of studies in human pathology, mouse genetics, early mouse embryo development, cell surface immunology and tissue culture. ES cells provided a crucial tool for manipulating mouse embryos to study mouse genetics, development and physiology. They have not only revolutionized experimental mammalian genetics but, with the advent of equivalent human ES cells, have now opened new vistas for regenerative medicine.

Citing Articles

Guidelines for Manufacturing and Application of Organoids: Kidney.

Kang H, Kim D, Kim Y, Shin K, Ahn S, Jung C Int J Stem Cells. 2024; 17(2):141-146.

PMID: 38764433 PMC: 11170122. DOI: 10.15283/ijsc24040.

Study on the spatial distribution patterns of histone modifications in Hippo pathway genes.

Su W, Zhang D, Zhang Q, Li Q Biophys Rep. 2023; 7(1):71-79.

PMID: 37288084 PMC: 10240540. DOI: 10.52601/bpr.2021.200042.

Atypical cell cycle profile of mouse embryonic stem cell is regulated by classic oncogenic and tumor suppressive genes in vitro.

Jiang J, Qiu T, Yang C, Yuan Y, Qin L, Zhang P Heliyon. 2022; 8(12):e11979.

PMID: 36578422 PMC: 9791322. DOI: 10.1016/j.heliyon.2022.e11979.

Zbtb34 promotes embryonic stem cell proliferation by elongating telomere length.

Liu Z, Wei X, Gao Y, Gao X, Li X, Zhong Y Aging (Albany NY). 2022; 14(17):7126-7136.

PMID: 36098743 PMC: 9512507. DOI: 10.18632/aging.204285.

Dynamic regulation of P-TEFb by 7SK snRNP is integral to the DNA damage response to regulate chemotherapy sensitivity.

Fang Y, Wang Y, Spector B, Xiao X, Yang C, Li P iScience. 2022; 25(9):104844.

PMID: 36034227 PMC: 9399290. DOI: 10.1016/j.isci.2022.104844.

References

Pierce G, DIXON Jr F . Testicular teratomas. II. Teratocarcinoma as an ascitic tumor. Cancer. 1959; 12(3):584-9. DOI: 10.1002/1097-0142(195905/06)12:3<584::aid-cncr2820120317>3.0.co;2-f. View

Evans M, Bradley A, Kuehn M, Robertson E . The ability of EK cells to form chimeras after selection of clones in G418 and some observations on the integration of retroviral vector proviral DNA into EK cells. Cold Spring Harb Symp Quant Biol. 1985; 50:685-9. DOI: 10.1101/sqb.1985.050.01.084. View

Solter D, Knowles B . Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1). Proc Natl Acad Sci U S A. 1978; 75(11):5565-9. PMC: 393007. DOI: 10.1073/pnas.75.11.5565. View

Evans M, Carlton M, Russ A . Gene trapping and functional genomics. Trends Genet. 1997; 13(9):370-4. DOI: 10.1016/s0168-9525(97)01240-7. View

Capecchi M . The making of a scientist II (Nobel Lecture). Chembiochem. 2008; 9(10):1530-43. DOI: 10.1002/cbic.200800239. View

Kahan B, EPHRUSSI B . Developmental potentialities of clonal in vitro cultures of mouse testicular teratoma. J Natl Cancer Inst. 1970; 44(5):1015-36. View

Nicolas J, Dubois P, Jakob H, Gaillard J, Jacob F . [Mouse teratocarcinoma: differentiation in cultures of a multipotential primitive cell line (author's transl)]. Ann Microbiol (Paris). 1975; 126(1):3-22. View

Mintz B, Illmensee K . Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proc Natl Acad Sci U S A. 1975; 72(9):3585-9. PMC: 433040. DOI: 10.1073/pnas.72.9.3585. View

Stern P, Willison K, LENNOX E, Galfre G, Milstein C, Secher D . Monoclonal antibodies as probes for differentiation and tumor-associated antigens: a Forssman specificity on teratocarcinoma stem cells. Cell. 1978; 14(4):775-83. DOI: 10.1016/0092-8674(78)90333-1. View

10.

Pierce Jr G, VERNEY E . An in vitro and in vivo study of differentiation in teratocarcinomas. Cancer. 1961; 14:1017-29. DOI: 10.1002/1097-0142(196109/10)14:5<1017::aid-cncr2820140516>3.0.co;2-p. View

11.

Zhou X, Sasaki H, Lowe L, Hogan B, Kuehn M . Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation. Nature. 1993; 361(6412):543-7. DOI: 10.1038/361543a0. View

12.

Rosenthal M, WISHNOW R, Sato G . In vitro growth and differetiation of clonal populations of multipotential mouse clls derived from a transplantable testicular teratocarcinoma. J Natl Cancer Inst. 1970; 44(5):1001-14. View

13.

Okita K, Ichisaka T, Yamanaka S . Generation of germline-competent induced pluripotent stem cells. Nature. 2007; 448(7151):313-7. DOI: 10.1038/nature05934. View

14.

Papaioannou V, McBurney M, Gardner R, Evans M . Fate of teratocarcinoma cells injected into early mouse embryos. Nature. 1975; 258(5530):70-73. DOI: 10.1038/258070a0. View

15.

Martin G, Evans M . The morphology and growth of a pluripotent teratocarcinoma cell line and its derivatives in tissue culture. Cell. 1974; 2(3):163-72. DOI: 10.1016/0092-8674(74)90090-7. View

16.

Evans M . Origin of mouse embryonal carcinoma cells and the possibility of their direct isolation into tissue culture. J Reprod Fertil. 1981; 62(2):625-31. DOI: 10.1530/jrf.0.0620625. View

17.

Evans M, Kaufman M . Establishment in culture of pluripotential cells from mouse embryos. Nature. 1981; 292(5819):154-6. DOI: 10.1038/292154a0. View

18.

Clarke A . Manipulating the germline: its impact on the study of carcinogenesis. Carcinogenesis. 2000; 21(3):435-41. DOI: 10.1093/carcin/21.3.435. View

19.

Artzt K, Dubois P, Bennett D, Condamine H, Babinet C, Jacob F . Surface antigens common to mouse cleavage embryos and primitive teratocarcinoma cells in culture. Proc Natl Acad Sci U S A. 1973; 70(10):2988-92. PMC: 427153. DOI: 10.1073/pnas.70.10.2988. View

20.

Jacob F . Mouse teratocarcinoma and embryonic antigens. Immunol Rev. 1977; 33:3-32. DOI: 10.1111/j.1600-065x.1977.tb00360.x. View