Motility and Chemotaxis in Campylobacter and Helicobacter

Overview

Journal Annu Rev Microbiol

Publisher Annual Reviews

Specialty Microbiology

Date 2011 Sep 24

PMID 21939377

Citations 168

Authors

Paphavee Lertsethtakarn

Karen M Ottemann

David R Hendrixson

Affiliations

Soon will be listed here.

Abstract

Flagellar motility of Campylobacter jejuni and Helicobacter pylori influences host colonization by promoting migration through viscous milieus such as gastrointestinal mucus. This review explores mechanisms C. jejuni and H. pylori employ to control flagellar biosynthesis and chemotactic responses. These microbes tightly control the activities of σ(54) and σ(28) to mediate ordered flagellar gene expression. In addition to phase-variable and posttranslational mechanisms, flagellar biosynthesis is regulated spatially and numerically so that only a certain number of organelles are placed at polar sites. To mediate chemotaxis, C. jejuni and H. pylori combine basic chemotaxis signal transduction components with several accessory proteins. H. pylori is unusual in that it lacks a methylation-based adaptation system and produces multiple CheV coupling proteins. Chemoreceptors in these bacteria contain nonconserved ligand binding domains, with several chemoreceptors matched to environmental signals. Together, these mechanisms allow for swimming motility that is essential for colonization.

Citing Articles

Flagellar Assembly Factor FliW2 De-Represses Helicobacter pylori FlaA-Mediated Motility by Allosteric Obstruction of Global Regulator CsrA.

Su M, Dickins B, Kiang F, Tsai W, Chen Y, Chen J Helicobacter. 2025; 30(2):e70019.

PMID: 40079448 PMC: 11905337. DOI: 10.1111/hel.70019.

leaves as source of anti- agents.

Tan A, Scortecci K, Cabral De Medeiros N, Kukula-Koch W, Butler T, Smith S Front Pharmacol. 2024; 15:1461447.

PMID: 39508036 PMC: 11537943. DOI: 10.3389/fphar.2024.1461447.

Time course transcriptomic profiling suggests Crp/Fnr transcriptional regulation of gene in a NO-reducing thermophile.

Tsuchiya J, Mino S, Fujiwara F, Okuma N, Ichihashi Y, Morris R iScience. 2024; 27(11):111074.

PMID: 39507244 PMC: 11539149. DOI: 10.1016/j.isci.2024.111074.

Prosthetic Joint Infection: Case Report and a Review of the Literature.

Jonckheere S, Mairesse C, Vandecandelaere P, Vanbiervliet J, Terryn W, Somers J Pathogens. 2024; 13(10).

PMID: 39452710 PMC: 11510586. DOI: 10.3390/pathogens13100838.

Increased Motility in and Changes in Its Virulence, Fitness, and Morphology Following Protein Expression on Ribosomes with Altered RsmA Methylation.

Salamaszynska-Guz A, Murawska M, Bacal P, Ostrowska A, Kwiecien E, Stefanska I Int J Mol Sci. 2024; 25(18).

PMID: 39337285 PMC: 11431728. DOI: 10.3390/ijms25189797.

References

Andermann T, Chen Y, Ottemann K . Two predicted chemoreceptors of Helicobacter pylori promote stomach infection. Infect Immun. 2002; 70(10):5877-81. PMC: 128301. DOI: 10.1128/IAI.70.10.5877-5881.2002. View

Wosten M, van Dijk L, Veenendaal A, de Zoete M, Bleumink-Pluijm N, van Putten J . Temperature-dependent FlgM/FliA complex formation regulates Campylobacter jejuni flagella length. Mol Microbiol. 2010; 75(6):1577-91. DOI: 10.1111/j.1365-2958.2010.07079.x. View

Josenhans C, Niehus E, Amersbach S, Horster A, Betz C, Drescher B . Functional characterization of the antagonistic flagellar late regulators FliA and FlgM of Helicobacter pylori and their effects on the H. pylori transcriptome. Mol Microbiol. 2002; 43(2):307-22. DOI: 10.1046/j.1365-2958.2002.02765.x. View

Beery J, Hugdahl M, Doyle M . Colonization of gastrointestinal tracts of chicks by Campylobacter jejuni. Appl Environ Microbiol. 1988; 54(10):2365-70. PMC: 204261. DOI: 10.1128/aem.54.10.2365-2370.1988. View

Berg H, Turner L . Movement of microorganisms in viscous environments. Nature. 1979; 278(5702):349-51. DOI: 10.1038/278349a0. View

Green J, Kahramanoglou C, Rahman A, Pender A, Charbonnel N, Fraser G . Recruitment of the earliest component of the bacterial flagellum to the old cell division pole by a membrane-associated signal recognition particle family GTP-binding protein. J Mol Biol. 2009; 391(4):679-90. DOI: 10.1016/j.jmb.2009.05.075. View

Sharma C, Hoffmann S, Darfeuille F, Reignier J, Findeiss S, Sittka A . The primary transcriptome of the major human pathogen Helicobacter pylori. Nature. 2010; 464(7286):250-5. DOI: 10.1038/nature08756. View

McGee D, Langford M, Watson E, Carter J, Chen Y, Ottemann K . Colonization and inflammation deficiencies in Mongolian gerbils infected by Helicobacter pylori chemotaxis mutants. Infect Immun. 2005; 73(3):1820-7. PMC: 1064941. DOI: 10.1128/IAI.73.3.1820-1827.2005. View

Szurmant H, Muff T, Ordal G . Bacillus subtilis CheC and FliY are members of a novel class of CheY-P-hydrolyzing proteins in the chemotactic signal transduction cascade. J Biol Chem. 2004; 279(21):21787-92. DOI: 10.1074/jbc.M311497200. View

10.

Cover T, Blaser M . Helicobacter pylori in health and disease. Gastroenterology. 2009; 136(6):1863-73. PMC: 3644425. DOI: 10.1053/j.gastro.2009.01.073. View

11.

Colland F, Rain J, Gounon P, Labigne A, Legrain P, de Reuse H . Identification of the Helicobacter pylori anti-sigma28 factor. Mol Microbiol. 2001; 41(2):477-87. DOI: 10.1046/j.1365-2958.2001.02537.x. View

12.

Yonekura K, Maki-Yonekura S, Namba K . Complete atomic model of the bacterial flagellar filament by electron cryomicroscopy. Nature. 2003; 424(6949):643-50. DOI: 10.1038/nature01830. View

13.

Logan S, Kelly J, Thibault P, Ewing C, Guerry P . Structural heterogeneity of carbohydrate modifications affects serospecificity of Campylobacter flagellins. Mol Microbiol. 2002; 46(2):587-97. DOI: 10.1046/j.1365-2958.2002.03185.x. View

14.

Sarkar M, Paul K, Blair D . Chemotaxis signaling protein CheY binds to the rotor protein FliN to control the direction of flagellar rotation in Escherichia coli. Proc Natl Acad Sci U S A. 2010; 107(20):9370-5. PMC: 2889077. DOI: 10.1073/pnas.1000935107. View

15.

Minamino T, Imada K, Namba K . Molecular motors of the bacterial flagella. Curr Opin Struct Biol. 2008; 18(6):693-701. DOI: 10.1016/j.sbi.2008.09.006. View

16.

Parkhill J, Wren B, Mungall K, Ketley J, Churcher C, Basham D . The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences. Nature. 2000; 403(6770):665-8. DOI: 10.1038/35001088. View

17.

Alexander R, Lowenthal A, Harshey R, Ottemann K . CheV: CheW-like coupling proteins at the core of the chemotaxis signaling network. Trends Microbiol. 2010; 18(11):494-503. PMC: 2975053. DOI: 10.1016/j.tim.2010.07.004. View

18.

Goon S, Ewing C, Lorenzo M, Pattarini D, Majam G, Guerry P . A sigma28-regulated nonflagella gene contributes to virulence of Campylobacter jejuni 81-176. Infect Immun. 2005; 74(1):769-72. PMC: 1346654. DOI: 10.1128/IAI.74.1.769-772.2006. View

19.

Terry K, Williams S, Connolly L, Ottemann K . Chemotaxis plays multiple roles during Helicobacter pylori animal infection. Infect Immun. 2005; 73(2):803-11. PMC: 547030. DOI: 10.1128/IAI.73.2.803-811.2005. View

20.

Vegge C, Brondsted L, Li Y, Bang D, Ingmer H . Energy taxis drives Campylobacter jejuni toward the most favorable conditions for growth. Appl Environ Microbiol. 2009; 75(16):5308-14. PMC: 2725471. DOI: 10.1128/AEM.00287-09. View