Antimicrobial Susceptibility of Salmonella Typhimurium Carrying the Outer Membrane Permeability Mutation SS-B

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1990 May 1

PMID 2193622

Citations 10

Authors

M Vaara

Affiliations

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Abstract

The antibiotic susceptibility profile of Salmonella typhimurium SS-B, a mutant susceptible to some antimicrobial agents, was studied in detail. Twenty-eight agents were tested, and eleven of these had MICs significantly lower (32- to greater than 250-fold) for the SS-B strain than for its parent. The drugs were generally hydrophobic or amphiphilic. Polymyxin B nonapeptide, which has a known outer membrane permeabilizing action, further reduced the MIC of several of these agents for the SS-B strain by a factor of approximately 10 to 30. In most cases, the resulting MICs were lower than the corresponding MICs for the parent strain grown in the presence of polymyxin B nonapeptide. In addition, the hydrophobic fluorescent probe N-phenyl naphthylamine was rapidly embedded in the membranes of the SS-B strain but was poorly embedded in those of the parent strain.

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References

Normark S, Boman H, Matsson E . Mutant of Escherichia coli with anomalous cell division and ability to decrease episomally and chromosomally mediated resistance to ampicillin and several other antibiotics. J Bacteriol. 1969; 97(3):1334-42. PMC: 249852. DOI: 10.1128/jb.97.3.1334-1342.1969. View

Vaara M, Jaakkola J . Sodium hexametaphosphate sensitizes Pseudomonas aeruginosa, several other species of Pseudomonas, and Escherichia coli to hydrophobic drugs. Antimicrob Agents Chemother. 1989; 33(10):1741-7. PMC: 172748. DOI: 10.1128/AAC.33.10.1741. View

Tamaki S, Matsuhashi M . Increase in sensitivity to antibiotics and lysozyme on deletion of lipopolysaccharides in Escherichia coli strains. J Bacteriol. 1973; 114(1):453-4. PMC: 251788. DOI: 10.1128/jb.114.1.453-454.1973. View

Rodolakis A, Thomas P, STARKA J . Morphological mutants of Escherichia coli. Isolation and ultrastructure of a chain-forming envC mutant. J Gen Microbiol. 1973; 75(2):409-16. DOI: 10.1099/00221287-75-2-409. View

Gustafsson P, Nordstrom K, Normark S . Outer penetration barrier of Escherichia coli K-12: kinetics of the uptake of gentian violet by wild type and envelope mutants. J Bacteriol. 1973; 116(2):893-900. PMC: 285460. DOI: 10.1128/jb.116.2.893-900.1973. View

Nikaido H . Outer membrane of Salmonella typhimurium. Transmembrane diffusion of some hydrophobic substances. Biochim Biophys Acta. 1976; 433(1):118-32. DOI: 10.1016/0005-2736(76)90182-6. View

Richmond M, Clark D, Wotton S . Indirect method for assessing the penetration of beta-lactamase-nonsusceptible penicillins and cephalosporins in Escherichia coli strains. Antimicrob Agents Chemother. 1976; 10(2):215-8. PMC: 429723. DOI: 10.1128/AAC.10.2.215. View

Stocker B, Nurminen M, Makela P . Mutants defective in the 33K outer membrane protein of Salmonella typhimurium. J Bacteriol. 1979; 139(2):376-83. PMC: 216879. DOI: 10.1128/jb.139.2.376-383.1979. View

Coleman Jr W, Leive L . Two mutations which affect the barrier function of the Escherichia coli K-12 outer membrane. J Bacteriol. 1979; 139(3):899-910. PMC: 218037. DOI: 10.1128/jb.139.3.899-910.1979. View

10.

Curtis N, Orr D, Ross G, Boulton M . Affinities of penicillins and cephalosporins for the penicillin-binding proteins of Escherichia coli K-12 and their antibacterial activity. Antimicrob Agents Chemother. 1979; 16(5):533-9. PMC: 352901. DOI: 10.1128/AAC.16.5.533. View

11.

Nikaido H, Nakae T . The outer membrane of Gram-negative bacteria. Adv Microb Physiol. 1979; 20:163-250. DOI: 10.1016/s0065-2911(08)60208-8. View

12.

Tecoma E, Wu D . Membrane deenergization by colicin K affects fluorescence of exogenously added but not biosynthetically esterified parinaric acid probes in Escherichia coli. J Bacteriol. 1980; 142(3):931-8. PMC: 294119. DOI: 10.1128/jb.142.3.931-938.1980. View

13.

Jensen S, Fecycz I, Campbell J . Nutritional factors controlling exocellular protease production by Pseudomonas aeruginosa. J Bacteriol. 1980; 144(2):844-7. PMC: 294740. DOI: 10.1128/jb.144.2.844-847.1980. View

14.

Ichihara S, Hussain M, Mizushima S . Characterization of new membrane lipoproteins and their precursors of Escherichia coli. J Biol Chem. 1981; 256(6):3125-9. View

15.

Starkova Z, Bonnaveiro N, STARKA J . Hydrolysis of phospholipids by phospholipase C in intact cells of wild-type and envelope mutants of Escherichia coli K12. FEBS Lett. 1981; 130(2):261-4. DOI: 10.1016/0014-5793(81)81134-9. View

16.

Uratani Y . Dansyl chloride labeling of Pseudomonas aeruginosa treated with pyocin R1: change in permeability of the cell envelope. J Bacteriol. 1982; 149(2):523-8. PMC: 216537. DOI: 10.1128/jb.149.2.523-528.1982. View

17.

Russell A, Furr J . Penetration of SQ 26,776, a new monobactam antibiotic, into Escherichia coli and Pseudomonas aeruginosa. J Antimicrob Chemother. 1982; 9(4):329-31. DOI: 10.1093/jac/9.4.329. View

18.

Vaara M, Vaara T . Sensitization of Gram-negative bacteria to antibiotics and complement by a nontoxic oligopeptide. Nature. 1983; 303(5917):526-8. DOI: 10.1038/303526a0. View

19.

Vaara M, Vaara T . Polycations sensitize enteric bacteria to antibiotics. Antimicrob Agents Chemother. 1983; 24(1):107-13. PMC: 185112. DOI: 10.1128/AAC.24.1.107. View

20.

Vaara M, Vaara T . Polycations as outer membrane-disorganizing agents. Antimicrob Agents Chemother. 1983; 24(1):114-22. PMC: 185113. DOI: 10.1128/AAC.24.1.114. View