Involvement of Cyclic AMP-dependent Protein Kinases in the Signal Transduction Pathway for Interleukin-1

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 1990 Jul 1

PMID 2192264

Citations 8

Authors

M Chedid

S B Mizel

Affiliations

Soon will be listed here.

Abstract

Expression of a highly specific protein inhibitor for cyclic AMP-dependent protein kinases in interleukin-1 (IL-1)-responsive cells blocked IL-1-induced gene transcription that was driven by the kappa immunoglobulin enhancer or the human immunodeficiency virus long terminal repeat. This inhibitor did not affect protein kinase C-mediated gene transcription, suggesting that cyclic AMP-dependent protein kinases are involved in the signal transduction pathway for IL-1 in a number of responsive cell types.

Citing Articles

Protein kinase-A-dependent osteoprotegerin production on interleukin-1 stimulation in human gingival fibroblasts is distinct from periodontal ligament fibroblasts.

Hormdee D, Nagasawa T, Kiji M, Yashiro R, Kobayashi H, Koshy G Clin Exp Immunol. 2005; 142(3):490-7.

PMID: 16297161 PMC: 1809540. DOI: 10.1111/j.1365-2249.2005.02937.x.

The polymeric immunoglobulin receptor (secretory component) in a human intestinal epithelial cell line is up-regulated by interleukin-1.

Hayashi M, Takenouchi N, Asano M, Kato M, Tsurumachi T, Saito T Immunology. 1998; 92(2):220-5.

PMID: 9415030 PMC: 1364062. DOI: 10.1046/j.1365-2567.1997.00341.x.

Thrombin stimulates production of interleukin-8 in human umbilical vein endothelial cells.

Ueno A, Murakami K, Yamanouchi K, Watanabe M, Kondo T Immunology. 1996; 88(1):76-81.

PMID: 8707354 PMC: 1456474. DOI: 10.1046/j.1365-2567.1996.d01-635.x.

A comparison of the effects of signal transduction inhibitors on oxidative burst and degranulation in IL-I beta stimulated bovine neutrophils.

Yu P, Czuprynski C Inflammation. 1995; 19(6):611-26.

PMID: 8595929 DOI: 10.1007/BF01534566.

Early events of human T lymphocyte activation are associated with type I protein kinase A activity.

Laxminarayana D, Berrada A, Kammer G J Clin Invest. 1993; 92(5):2207-14.

PMID: 8227335 PMC: 288400. DOI: 10.1172/JCI116823.

References

Whitehouse S, Walsh D . Inhibitor protein of the cAMP-dependent protein kinase: characteristics and purification. Methods Enzymol. 1983; 99:80-93. DOI: 10.1016/0076-6879(83)99044-4. View

Nilson J, Bokar J, Andersen B, Bohinski R, Kennedy G, Keri R . CRE-binding proteins interact cooperatively to enhance placental-specific expression of the glycoprotein hormone alpha-subunit gene. Ann N Y Acad Sci. 1989; 564:77-85. DOI: 10.1111/j.1749-6632.1989.tb25889.x. View

Short J, Wynshaw-Boris A, Short H, Hanson R . Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains. J Biol Chem. 1986; 261(21):9721-6. View

Montminy M, Sevarino K, Wagner J, Mandel G, Goodman R . Identification of a cyclic-AMP-responsive element within the rat somatostatin gene. Proc Natl Acad Sci U S A. 1986; 83(18):6682-6. PMC: 386573. DOI: 10.1073/pnas.83.18.6682. View

Sen R, Baltimore D . Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Cell. 1986; 47(6):921-8. DOI: 10.1016/0092-8674(86)90807-x. View

Atchison M, PERRY R . The role of the kappa enhancer and its binding factor NF-kappa B in the developmental regulation of kappa gene transcription. Cell. 1987; 48(1):121-8. DOI: 10.1016/0092-8674(87)90362-x. View

Nabel G, Baltimore D . An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature. 1987; 326(6114):711-3. DOI: 10.1038/326711a0. View

Silver B, Bokar J, Virgin J, Vallen E, Milsted A, Nilson J . Cyclic AMP regulation of the human glycoprotein hormone alpha-subunit gene is mediated by an 18-base-pair element. Proc Natl Acad Sci U S A. 1987; 84(8):2198-202. PMC: 304616. DOI: 10.1073/pnas.84.8.2198. View

Montminy M, Bilezikjian L . Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene. Nature. 1987; 328(6126):175-8. DOI: 10.1038/328175a0. View

10.

Grove J, Price D, Goodman H, Avruch J . Recombinant fragment of protein kinase inhibitor blocks cyclic AMP-dependent gene transcription. Science. 1987; 238(4826):530-3. DOI: 10.1126/science.2821622. View

11.

Berg D, Mooney P, Baez M, Grinnell B . Tandem promoter/enhancer units create a versatile regulatory element for the expression of genes in mammalian cells. Nucleic Acids Res. 1988; 16(4):1635. PMC: 336356. DOI: 10.1093/nar/16.4.1635. View

12.

Roesler W, Vandenbark G, Hanson R . Cyclic AMP and the induction of eukaryotic gene transcription. J Biol Chem. 1988; 263(19):9063-6. View

13.

Akerblom I, Slater E, Beato M, Baxter J, Mellon P . Negative regulation by glucocorticoids through interference with a cAMP responsive enhancer. Science. 1988; 241(4863):350-3. DOI: 10.1126/science.2838908. View

14.

Shirakawa F, Yamashita U, Chedid M, Mizel S . Cyclic AMP--an intracellular second messenger for interleukin 1. Proc Natl Acad Sci U S A. 1988; 85(21):8201-5. PMC: 282395. DOI: 10.1073/pnas.85.21.8201. View

15.

Osborn L, Kunkel S, Nabel G . Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc Natl Acad Sci U S A. 1989; 86(7):2336-40. PMC: 286907. DOI: 10.1073/pnas.86.7.2336. View

16.

CROSS S, Halden N, Lenardo M, Leonard W . Functionally distinct NF-kappa B binding sites in the immunoglobulin kappa and IL-2 receptor alpha chain genes. Science. 1989; 244(4903):466-9. DOI: 10.1126/science.2497520. View

17.

Hansen C, Javaux F, Juvenal G, Vassart G, Christophe D . cAMP-dependent binding of a trans-acting factor to the thyroglobulin promoter. Biochem Biophys Res Commun. 1989; 160(2):722-31. DOI: 10.1016/0006-291x(89)92493-5. View

18.

Chedid M, Shirakawa F, Naylor P, Mizel S . Signal transduction pathway for IL-1. Involvement of a pertussis toxin-sensitive GTP-binding protein in the activation of adenylate cyclase. J Immunol. 1989; 142(12):4301-6. View

19.

Shirakawa F, Chedid M, Suttles J, Pollok B, Mizel S . Interleukin 1 and cyclic AMP induce kappa immunoglobulin light-chain expression via activation of an NF-kappa B-like DNA-binding protein. Mol Cell Biol. 1989; 9(3):959-64. PMC: 362684. DOI: 10.1128/mcb.9.3.959-964.1989. View

20.

Mellon P, Clegg C, Correll L, McKnight G . Regulation of transcription by cyclic AMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1989; 86(13):4887-91. PMC: 297520. DOI: 10.1073/pnas.86.13.4887. View