Mouse Genomic Variation and Its Effect on Phenotypes and Gene Regulation

Overview

Journal Nature

Specialty Science

Date 2011 Sep 17

PMID 21921910

Citations 1016

Authors

Thomas M Keane

Leo Goodstadt

Petr Danecek

Michael A White

Kim Wong

Binnaz Yalcin

Andreas Heger

Avigail Agam

Guy Slater

Martin Goodson

Nicholas A Furlotte

Eleazar Eskin

Christoffer Nellaker

Helen Whitley

James Cleak

Deborah Janowitz

Polinka Hernandez-Pliego

Andrew Edwards

T Grant Belgard

Peter L Oliver

Rebecca E McIntyre

Amarjit Bhomra

Jerome Nicod

Xiangchao Gan

Wei Yuan

Louise van der Weyden

Charles A Steward

Sendu Bala

Jim Stalker

Richard Mott

Richard Durbin

Ian J Jackson

Anne Czechanski

Jose Afonso Guerra-Assuncao

Leah Rae Donahue

Laura G Reinholdt

Bret A Payseur

Chris P Ponting

Ewan Birney

Jonathan Flint

David J Adams

Affiliations

Soon will be listed here.

Abstract

We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more variants than previously known. We use these genomes to explore the phylogenetic history of the laboratory mouse and to examine the functional consequences of allele-specific variation on transcript abundance, revealing that at least 12% of transcripts show a significant tissue-specific expression bias. By identifying candidate functional variants at 718 quantitative trait loci we show that the molecular nature of functional variants and their position relative to genes vary according to the effect size of the locus. These sequences provide a starting point for a new era in the functional analysis of a key model organism.

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