Reconstruction of Integrin Activation

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2011 Sep 17

PMID 21921044

Citations 61

Authors

Feng Ye

Chungho Kim

Mark H Ginsberg

Affiliations

Soon will be listed here.

Abstract

Integrins are integral membrane proteins that mediate cell-matrix and cell-cell adhesion. They are important for vascular development and hematopoiesis, immune and inflammatory responses, and hemostasis. Integrins are also signaling receptors that can transmit information bidirectionally across plasma membranes. Research in the past 2 decades has made progress in unraveling the mechanisms of integrin signaling and brings the field to the moment of attempting synthetic reconstruction of the signaling pathways in vitro. Reconstruction of biologic processes provides stringent tests of our understanding of the process, as evidenced by studies of other biologic machines, such as ATP synthase, lactose permease, and G-protein-coupled receptors. Here, we review recent progress in reconstructing integrin signaling and the insights that we have gained through these experiments.

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