Malabaricone C from Myristica Cinnamomea Exhibits Anti-quorum Sensing Activity

Overview

Journal J Nat Prod

Date 2011 Sep 14

PMID 21910441

Citations 51

Authors

Yee Meng Chong

Wai Fong Yin

Chia Yong Ho

Mohamad Rais Mustafa

A Hamid A Hadi

Khalijah Awang

Putri Narrima

Chong-Lek Koh

David R Appleton

Kok-Gan Chan

Affiliations

Soon will be listed here.

Abstract

A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026 when grown in the presence of a cognate signaling molecule, N-3-oxohexanoyl-homoserine lactone. Furthermore, 1 inhibited the quorum sensing-regulated pyocyanin production and biofilm formation in Pseudomonas aeruginosa PAO1. These results suggest that the anti-quorum sensing activity of 1 and related molecules should be investigated further.

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