A Review on Antimicrobial Strategies in Mitigating Biofilm-associated Infections on Medical Implants

Overview

Journal Curr Res Microb Sci

Specialty Microbiology

Date 2024 Mar 21

PMID 38510214

Authors

Lohita Kadirvelu

Sowmiya Sri Sivaramalingam

Deepsikha Jothivel

Dhivia Dharshika Chithiraiselvan

Deenadayalan Karaiyagowder Govindarajan

Kumaravel Kandaswamy

Affiliations

Soon will be listed here.

Abstract

Biomedical implants are crucial in providing support and functionality to patients with missing or defective body parts. However, implants carry an inherent risk of bacterial infections that are biofilm-associated and lead to significant complications. These infections often result in implant failure, requiring replacement by surgical restoration. Given these complications, it is crucial to study the biofilm formation mechanism on various biomedical implants that will help prevent implant failures. Therefore, this comprehensive review explores various types of implants (e.g., dental implant, orthopedic implant, tracheal stent, breast implant, central venous catheter, cochlear implant, urinary catheter, intraocular lens, and heart valve) and medical devices (hemodialyzer and pacemaker) in use. In addition, the mechanism of biofilm formation on those implants, and their pathogenesis were discussed. Furthermore, this article critically reviews various approaches in combating implant-associated infections, with a special emphasis on novel non-antibiotic alternatives to mitigate biofilm infections.

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