Graphite Oxide: a Selective and Highly Efficient Oxidant of Thiols and Sulfides

Overview

Journal Org Biomol Chem

Publisher Royal Society of Chemistry

Specialties Biochemistry
Chemistry

Date 2011 Sep 13

PMID 21909587

Citations 14

Authors

Daniel R Dreyer

Hong-Peng Jia

Alexander D Todd

Jianxin Geng

Christopher W Bielawski

Affiliations

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Abstract

The selective oxidation of thiols to disulfides and sulfides to sulfoxides using graphite oxide (GO), a heterogeneous carbocatalyst obtained from low cost, commercial starting materials is described. The aforementioned oxidation reactions were found to proceed rapidly (as short as 10 min in some cases) and in good yield (51-100%) (19 examples). No over-oxidation of the substrates was observed, and GO's heterogeneous nature facilitated isolation and purification of the target products.

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