Structures of Giant Icosahedral Eukaryotic DsDNA Viruses

Overview

Journal Curr Opin Virol

Publisher Elsevier

Specialty Microbiology

Date 2011 Sep 13

PMID 21909343

Citations 19

Authors

Chuan Xiao

Michael G Rossmann

Affiliations

Soon will be listed here.

Abstract

In the last twenty years, numerous giant, dsDNA, icosahedral viruses have been discovered and assigned to the nucleocytoplasmic large dsDNA virus (NCLDV) clade. The major capsid proteins of these viruses consist of two consecutive jelly-roll domains, assembled into trimers, with pseudo 6-fold symmetry. The capsomers are assembled into arrays that have either p6 (as in Paramecium bursaria Chlorella virus-1) or p3 symmetry (as in Mimivirus). Most of the NCLDV viruses have a membrane that separates the nucleocapsid from the external capsid.

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