Prenatal Protein Malnutrition Alters the Proportion but Not Numbers of Parvalbumin-immunoreactive Interneurons in the Hippocampus of the Adult Sprague-Dawley Rat

Overview

Journal Nutr Neurosci

Specialties Neurology
Nutritional Sciences

Date 2011 Sep 10

PMID 21902887

Citations 5

Authors

James P Lister

Gene J Blatt

Thomas L Kemper

John Tonkiss

William A DeBassio

Janina R Galler

Douglas L Rosene

Affiliations

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Abstract

Prenatal protein malnutrition alters the structure and function of the adult rat hippocampal formation. The current study examines the effect of prenatal protein malnutrition on numbers of parvalbumin-immunoreactive (PV-IR) GABAergic interneurons, which are important for perisomatic inhibition of hippocampal pyramidal neurons. Brain sections from prenatally protein malnourished and normally nourished rats were stained for parvalbumin and PV-IR neurons were quantified using stereology in the dentate gyrus, CA3/2 and CA1 subfields, and the subiculum for both cerebral hemispheres. Results demonstrated that prenatal malnutrition did not affect the number of PV-IR interneurons in the hippocampus. Since prenatal protein malnutrition reduces total neuron numbers in the CA1 subfield (1), this results in an altered ratio of PV-IR interneurons to total neuronal numbers (from 1:22.9 in controls to 1:20.5 in malnourished rats). Additionally, there was no hemispheric asymmetry of either PV-IR neuron numbers or ratio of PV-IR:total neuron numbers.

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