Increased Pfmdr1 Copy Number and Sequence Polymorphisms in Plasmodium Falciparum Isolates from Sudanese Malaria Patients Treated with Artemether-lumefantrine

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2011 Sep 8

PMID 21896916

Citations 48

Authors

Nahla B Gadalla

Ishag Adam

Salah-Eldin Elzaki

Sahar Bashir

Izdihar Mukhtar

Mary Oguike

Amal Gadalla

Fathi Mansour

David Warhurst

Badria B El-Sayed

Colin J Sutherland

Affiliations

Soon will be listed here.

Abstract

Molecular markers for surveillance of Plasmodium falciparum resistance to current antimalarials are sorely needed. A 28-day efficacy study of artemether-lumefantrine in eastern Sudan identified 5 treatment failures among 100 evaluable patients; 9 further individuals were parasite positive by PCR during follow-up. Polymorphisms in pfatpase6 and pfmdr1 were evaluated by DNA sequencing. One individual carried parasites with a novel pfmdr1 polymorphism (F1044L). pfmdr1 gene amplification in parasites prior to treatment occurred in three individuals who had recurrent infection during follow-up.

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