Serum Antibody Responses to Polymorphic Cryptosporidium Mucin Antigen in Bangladeshi Children with Cryptosporidiosis

Overview

Journal Am J Trop Med Hyg

Specialty Tropical Medicine

Date 2011 Sep 8

PMID 21896806

Citations 4

Authors

Olivia Lai

Christopher Morris

Sabeena Ahmed

Mohammed Mahbubul Karim

Wasif Khan

Honorine Ward

Roberta OConnor

Affiliations

Soon will be listed here.

Abstract

Cryptosporidium is a significant cause of diarrheal disease in children in developing countries. The sporozoite antigen Muc4 is important for infection of host cells, and could be a candidate vaccine antigen. However, this antigen is polymorphic between Cryptosporidium hominis and C. parvum. We investigated antibody responses to C. hominis Muc4 and C. parvum Muc4 antigen in children in Bangladesh infected with C. hominis. Antibody responses were compared between children with cryptosporidial diarrhea (cases) and uninfected children with diarrhea (controls). There was a significant IgM response to Muc4 from both species in cases compared with controls, which increased over time, and was higher in children with persistent diarrhea. Despite sequence polymorphisms, antibody responses to C. hominis Muc4 and C. parvum Muc4 were significantly correlated. These results suggest that the human antibody response to Muc4 is cross-reactive between species, but in young children does not mature to an IgG response within the period observed in this study.

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