Mechanical-tactile Stimulation (MTS) Intervention in a Neonatal Stress Model Improves Long-term Outcomes on Bone

Overview

Journal J Musculoskelet Neuronal Interact

Specialties Neurology
Orthopedics
Physiology

Date 2011 Sep 3

PMID 21885898

Citations 2

Authors

S Haley

S OGrady

K Gulliver

B Bowman

R Baldassarre

S Miller

R H Lane

L J Moyer-Mileur

Affiliations

Soon will be listed here.

Abstract

Objectives: Neonatal stress impairs postnatal bone mineralization. Evidence suggests that mechanical tactile stimulation (MTS) in early life decreases stress hormones and improves bone mineralization. Insulin-like growth factor (IGF1) is impacted by stress and essential to bone development. We hypothesized that MTS administered during neonatal stress would improve bone phenotype in later life. We also predicted an increase in bone specific mRNA expression of IGF1 related pathways.

Methods: Neonatal stress (STRESS) and MTS (STRESS+10 min of MTS) were given from D6 to D10 of rat life and tissue was harvested on D60 of life. Dual energy x-ray absorptiometry (DXA), bone morphometry, serum osteocalcin, type I procollagen N-terminal propeptide (PINP), tartrate-resistant acid phosphatase (TRAP), and bone and liver mRNA levels of IGF1, IGF1 receptor (IGF1R), and growth hormone receptor (GHR) were measured.

Results: Stress resulted in reduced bone area and bone mineral content (BMC) compared to naive control (CTL). MTS intervention increased BMC and tibial growth plate width compared to STRESS. MTS also resulted in higher osteocalcin, and, in males, lower TRAP (p<0.05). MTS resulted in three-fold, two-fold, and six-fold higher bone specific IGF1, IGF1R, and GHR, respectively (p ≤ 0.001) compared to STRESS.

Conclusions: MTS in early postnatal life improves long-term bone mineralization. IGF1 and related pathways may explain improved BMC.

Citing Articles

Thai traditional massage increases biochemical markers of bone formation in postmenopausal women: a randomized crossover trial.

Saetung S, Chailurkit L, Ongphiphadhanakul B BMC Complement Altern Med. 2013; 13:69.

PMID: 23530566 PMC: 3770450. DOI: 10.1186/1472-6882-13-69.

Tactile/kinesthetic stimulation (TKS) increases tibial speed of sound and urinary osteocalcin (U-MidOC and unOC) in premature infants (29-32weeks PMA).

Haley S, Beachy J, Ivaska K, Slater H, Smith S, Moyer-Mileur L Bone. 2012; 51(4):661-6.

PMID: 22846674 PMC: 3434881. DOI: 10.1016/j.bone.2012.07.016.

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