Tactile/kinesthetic Stimulation (TKS) Increases Tibial Speed of Sound and Urinary Osteocalcin (U-MidOC and UnOC) in Premature Infants (29-32weeks PMA)

Overview

Journal Bone

Specialties Endocrinology
Orthopedics

Date 2012 Aug 1

PMID 22846674

Citations 10

Authors

S Haley

J Beachy

K K Ivaska

H Slater

S Smith

L J Moyer-Mileur

Affiliations

Soon will be listed here.

Abstract

Preterm delivery (<37 weeks post-menstrual age) is associated with suboptimal bone mass. We hypothesized that tactile/kinesthetic stimulation (TKS), a form of infant massage that incorporates kinesthetic movement, would increase bone strength and markers of bone accretion in preterm infants. Preterm, AGA infants (29-32 weeks) were randomly assigned to TKS (N=20) or Control (N=20). Twice daily TKS was provided 6 days per week for 2 weeks. Control infants received the same care without TKS treatment. Treatment was masked to parents, health care providers, and study personnel. Baseline and week two measures were collected for tibial speed of sound (tSOS, m/sec), a surrogate for bone strength, by quantitative ultrasound (Sunlight8000) and urine markers of bone metabolism, pyridinium crosslinks and osteocalcin (U-MidOC and unOC). Infant characteristics at birth and study entry as well as energy/nutrient intake were similar between TKS and Control. TKS intervention attenuated the decrease in tSOS observed in Control infants (p<0.05). Urinary pyridinium crosslinks decreased over time in both TKS and CTL (p<0.005). TKS infants experienced greater increases in urinary osteocalcin (U-MidOC, p<0.001 and unOC, p<0.05). We conclude that TKS improves bone strength in premature infants by attenuating the decrease that normally follows preterm birth. Further, biomarkers of bone metabolism suggest a modification in bone turnover in TKS infants in favor of bone accretion. Taken together, we speculate that TKS improves bone mineralization.

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References

Hozuki T, Imai T, Tsuda E, Matsumura A, Yamamoto D, Toyoshima T . Response of serum carboxylated and undercarboxylated osteocalcin to risedronate monotherapy and combined therapy with vitamin K(2) in corticosteroid-treated patients: a pilot study. Intern Med. 2010; 49(5):371-6. DOI: 10.2169/internalmedicine.49.2551. View

Griffin I, Cooke R . Development of whole body adiposity in preterm infants. Early Hum Dev. 2012; 88 Suppl 1:S19-24. DOI: 10.1016/j.earlhumdev.2011.12.023. View

Rigo J, Pieltain C, Salle B, Senterre J . Enteral calcium, phosphate and vitamin D requirements and bone mineralization in preterm infants. Acta Paediatr. 2007; 96(7):969-74. DOI: 10.1111/j.1651-2227.2007.00336.x. View

Slemenda C, Miller J, Hui S, Reister T, JOHNSTON Jr C . Role of physical activity in the development of skeletal mass in children. J Bone Miner Res. 1991; 6(11):1227-33. DOI: 10.1002/jbmr.5650061113. View

Lee H . The effect of infant massage on weight gain, physiological and behavioral responses in premature infants. Taehan Kanho Hakhoe Chi. 2006; 35(8):1451-60. DOI: 10.4040/jkan.2005.35.8.1451. View

Ferron M, McKee M, Levine R, Ducy P, Karsenty G . Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice. Bone. 2011; 50(2):568-75. PMC: 3181267. DOI: 10.1016/j.bone.2011.04.017. View

Moyer-Mileur L, Haley S, Gulliver K, Thomson A, Slater H, Barrett B . Mechanical-tactile stimulation (MTS) during neonatal stress prevents hyperinsulinemia despite stress-induced adiposity in weanling rat pups. Early Hum Dev. 2011; 87(3):159-63. PMC: 3228309. DOI: 10.1016/j.earlhumdev.2010.12.001. View

Mercy J, Dillon B, Morris J, Emmerson A, Mughal M . Relationship of tibial speed of sound and lower limb length to nutrient intake in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2007; 92(5):F381-5. PMC: 2675363. DOI: 10.1136/adc.2006.105742. View

Field T, Hernandez-Reif M, Diego M, Schanberg S, Kuhn C . Cortisol decreases and serotonin and dopamine increase following massage therapy. Int J Neurosci. 2005; 115(10):1397-413. DOI: 10.1080/00207450590956459. View

10.

Ho Y, Lee R, Chow C, Pang M . Impact of massage therapy on motor outcomes in very low-birthweight infants: randomized controlled pilot study. Pediatr Int. 2009; 52(3):378-85. DOI: 10.1111/j.1442-200X.2009.02964.x. View

11.

Field T, Diego M, Hernandez-Reif M . Preterm infant massage therapy research: a review. Infant Behav Dev. 2010; 33(2):115-24. PMC: 2844909. DOI: 10.1016/j.infbeh.2009.12.004. View

12.

Chan G, Armstrong C, Moyer-Mileur L, Hoff C . Growth and bone mineralization in children born prematurely. J Perinatol. 2008; 28(9):619-23. DOI: 10.1038/jp.2008.59. View

13.

Specker B, Johannsen N, Binkley T, Finn K . Total body bone mineral content and tibial cortical bone measures in preschool children. J Bone Miner Res. 2002; 16(12):2298-305. DOI: 10.1359/jbmr.2001.16.12.2298. View

14.

Moyer-Mileur L, Brunstetter V, McNaught T, Gill G, Chan G . Daily physical activity program increases bone mineralization and growth in preterm very low birth weight infants. Pediatrics. 2000; 106(5):1088-92. DOI: 10.1542/peds.106.5.1088. View

15.

Mericq V . Prematurity and insulin sensitivity. J Endocrinol Invest. 2011; 34(2):145-9. DOI: 10.1007/BF03347045. View

16.

Fewtrell M . Early nutritional predictors of long-term bone health in preterm infants. Curr Opin Clin Nutr Metab Care. 2011; 14(3):297-301. DOI: 10.1097/MCO.0b013e328345361b. View

17.

Vickers A, Ohlsson A, Lacy J, Horsley A . Massage for promoting growth and development of preterm and/or low birth-weight infants. Cochrane Database Syst Rev. 2004; (2):CD000390. PMC: 6956667. DOI: 10.1002/14651858.CD000390.pub2. View

18.

Rack B, Lochmuller E, Janni W, Lipowsky G, Engelsberger I, Friese K . Ultrasound for the assessment of bone quality in preterm and term infants. J Perinatol. 2011; 32(3):218-26. DOI: 10.1038/jp.2011.82. View

19.

Weiler H, Yuen C, Seshia M . Growth and bone mineralization of young adults weighing less than 1500 g at birth. Early Hum Dev. 2002; 67(1-2):101-12. DOI: 10.1016/s0378-3782(02)00003-8. View

20.

Foldes A, Rimon A, Keinan D, Popovtzer M . Quantitative ultrasound of the tibia: a novel approach for assessment of bone status. Bone. 1995; 17(4):363-7. DOI: 10.1016/s8756-3282(95)00244-8. View