Dopamine-dependent Long-term Depression is Expressed in Striatal Spiny Neurons of Both Direct and Indirect Pathways: Implications for Parkinson's Disease

Overview

Journal J Neurosci

Specialty Neurology

Date 2011 Sep 2

PMID 21880913

Citations 54

Authors

Vincenza Bagetta

Barbara Picconi

Silvia Marinucci

Carmelo Sgobio

Valentina Pendolino

Veronica Ghiglieri

Francesca R Fusco

Carmen Giampa

Paolo Calabresi

Affiliations

Soon will be listed here.

Abstract

Striatal medium spiny neurons (MSNs) are divided into two subpopulations exerting distinct effects on motor behavior. Transgenic mice carrying bacterial artificial chromosome (BAC) able to confer cell type-specific expression of enhanced green fluorescent protein (eGFP) for dopamine (DA) receptors have been developed to characterize differences between these subpopulations. Analysis of these mice, in contrast with original pioneering studies, showed that striatal long-term depression (LTD) was expressed in indirect but not in the direct pathway MSNs. To address this mismatch, we applied a new approach using combined BAC technology and receptor immunohistochemistry. We demonstrate that, in physiological conditions, DA-dependent LTD is expressed in both pathways showing that the lack of synaptic plasticity found in D(1) eGFP mice is associated to behavioral deficits. Our findings suggest caution in the use of this tool and indicate that the "striatal segregation" hypothesis might not explain all synaptic dysfunctions in Parkinson's disease.

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