Dopamine-dependent Synaptic Plasticity in Striatum During in Vivo Development

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2001 Feb 7

PMID 11158626

Citations 56

Authors

K Tang

M J Low

D K Grandy

D M Lovinger

Affiliations

Soon will be listed here.

Abstract

The neurotransmitters dopamine (DA) and glutamate in the striatum play key roles in movement and cognition, and they are implicated in disorders of the basal ganglia such as Parkinson's disease. Excitatory synapses in striatum undergo a form of developmental plasticity characterized by a decrease in glutamate release probability. Here we demonstrate that this form of synaptic plasticity is DA and DA D2 receptor dependent. Analysis of spontaneous synaptic responses indicates that a presynaptic mechanism involving inhibition of neurotransmitter release underlies the developmental plasticity. We suggest that a major role of DA in the striatum is to initiate mechanisms that regulate the efficacy of excitatory striatal synapses, producing a decrease in glutamate release.

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