Striatal Volumes in Pediatric Bipolar Patients with and Without Comorbid ADHD

Overview

Journal Psychiatry Res

Specialty Psychiatry

Date 2011 Aug 31

PMID 21875781

Citations 8

Authors

Isabelle Yisha Liu

Meghan Howe

Amy Garrett

Asya Karchemskiy

Ryan Kelley

Dylan Alegria

Allan Reiss

Kiki Chang

Affiliations

Soon will be listed here.

Abstract

The most prevalent comorbid disorder in pediatric bipolar disorder (BD) is attention-deficit/hyperactivity disorder (ADHD). As caudate volume abnormalities have been demonstrated in both BD and ADHD, this study sought to determine whether these findings could be attributed to separable effects from either diagnosis. High resolution anatomical magnetic resonance (MRI) images were obtained from youth in 4 groups: BD with comorbid ADHD (n=17), BD without comorbid ADHD (n=12), youth with ADHD alone (n=11), and healthy control subjects (n=24). Caudate, putamen, and globus pallidus volumes were manually traced for each subject using BrainImageJava software by a reliable rater blinded to diagnosis. There was a significant effect of diagnosis on striatal volumes, with ADHD associated with decreased caudate and putamen volumes, and BD associated with increased caudate, putamen, and globus pallidus volumes. Thus, the presence or absence of comorbid ADHD in patients with BD was associated with distinct alterations in caudate volumes, suggesting that these groups have different, but related, mechanisms of neuropathology.

Citing Articles

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