Basal Ganglia Volume and Shape in Children with Attention Deficit Hyperactivity Disorder

Overview

Journal Am J Psychiatry

Specialty Psychiatry

Date 2008 Nov 19

PMID 19015232

Citations 121

Authors

Anqi Qiu

Deana Crocetti

Marcy Adler

E Mark Mahone

Martha B Denckla

Michael I Miller

Stewart H Mostofsky

Affiliations

Soon will be listed here.

Abstract

Objective: Volumetric abnormalities of basal ganglia have been associated with attention deficit hyperactivity disorder (ADHD), especially in boys. To specify localization of these abnormalities, large deformation diffeomorphic metric mapping (LDDMM) was used to examine the effects of ADHD, sex, and their interaction on basal ganglia shapes.

Method: The basal ganglia (caudate, putamen, globus pallidus) were manually delineated on magnetic resonance imaging from 66 typically developing children (35 boys) and 47 children (27 boys) with ADHD. LDDMM mappings from 35 typically developing children were used to generate basal ganglia templates. Shape variations of each structure relative to the template were modeled for each subject as a random field using Laplace-Beltrami basis functions in the template coordinates. Linear regression was used to examine group differences in volumes and shapes of the basal ganglia.

Results: Boys with ADHD showed significantly smaller basal ganglia volumes compared with typically developing boys, and LDDMM revealed the groups remarkably differed in basal ganglia shapes. Volume compression was seen bilaterally in the caudate head and body and anterior putamen as well as in the left anterior globus pallidus and right ventral putamen. Volume expansion was most pronounced in the posterior putamen. No volume or shape differences were revealed in girls with ADHD.

Conclusions: The shape compression pattern of basal ganglia in boys with ADHD suggests that ADHD-associated deviations from typical brain development involve multiple frontal-subcortical control loops, including circuits with premotor, oculomotor, and prefrontal cortices. Further investigations employing brain-behavior analyses will help to discern the task-dependent contributions of these circuits to impaired response control that is characteristic of ADHD.

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References

Castellanos F, Giedd J, Marsh W, Hamburger S, Vaituzis A, Dickstein D . Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder. Arch Gen Psychiatry. 1996; 53(7):607-16. DOI: 10.1001/archpsyc.1996.01830070053009. View

Heilman K, Voeller K, Nadeau S . A possible pathophysiologic substrate of attention deficit hyperactivity disorder. J Child Neurol. 1991; 6 Suppl:S76-81. DOI: 10.1177/0883073891006001s09. View

Semrud-Clikeman M, Steingard R, Filipek P, Biederman J, Bekken K, Renshaw P . Using MRI to examine brain-behavior relationships in males with attention deficit disorder with hyperactivity. J Am Acad Child Adolesc Psychiatry. 2000; 39(4):477-84. DOI: 10.1097/00004583-200004000-00017. View

Singer H, Reiss A, Brown J, Aylward E, Shih B, Chee E . Volumetric MRI changes in basal ganglia of children with Tourette's syndrome. Neurology. 1993; 43(5):950-6. DOI: 10.1212/wnl.43.5.950. View

Qiu A, Younes L, Wang L, Ratnanather J, Gillepsie S, Kaplan G . Combining anatomical manifold information via diffeomorphic metric mappings for studying cortical thinning of the cingulate gyrus in schizophrenia. Neuroimage. 2007; 37(3):821-33. PMC: 4465219. DOI: 10.1016/j.neuroimage.2007.05.007. View

Haber S . The primate basal ganglia: parallel and integrative networks. J Chem Neuroanat. 2004; 26(4):317-30. DOI: 10.1016/j.jchemneu.2003.10.003. View

Wolosin S, Richardson M, Hennessey J, Denckla M, Mostofsky S . Abnormal cerebral cortex structure in children with ADHD. Hum Brain Mapp. 2007; 30(1):175-84. PMC: 2883170. DOI: 10.1002/hbm.20496. View

Qiu A, Younes L, Miller M . Intrinsic and extrinsic analysis in computational anatomy. Neuroimage. 2007; 39(4):1803-14. DOI: 10.1016/j.neuroimage.2007.08.043. View

Akkal D, Dum R, Strick P . Supplementary motor area and presupplementary motor area: targets of basal ganglia and cerebellar output. J Neurosci. 2007; 27(40):10659-73. PMC: 6672811. DOI: 10.1523/JNEUROSCI.3134-07.2007. View

10.

Vaillant M, Qiu A, Glaunes J, Miller M . Diffeomorphic metric surface mapping in subregion of the superior temporal gyrus. Neuroimage. 2006; 34(3):1149-59. PMC: 3140704. DOI: 10.1016/j.neuroimage.2006.08.053. View

11.

Mostofsky S, Simmonds D . Response inhibition and response selection: two sides of the same coin. J Cogn Neurosci. 2008; 20(5):751-61. DOI: 10.1162/jocn.2008.20500. View

12.

Overmeyer S, Bullmore E, Suckling J, Simmons A, Williams S, Santosh P . Distributed grey and white matter deficits in hyperkinetic disorder: MRI evidence for anatomical abnormality in an attentional network. Psychol Med. 2001; 31(8):1425-35. DOI: 10.1017/s0033291701004706. View

13.

Makris N, Biederman J, Valera E, Bush G, Kaiser J, Kennedy D . Cortical thinning of the attention and executive function networks in adults with attention-deficit/hyperactivity disorder. Cereb Cortex. 2006; 17(6):1364-75. DOI: 10.1093/cercor/bhl047. View

14.

Qiu A, Bitouk D, Miller M . Smooth functional and structural maps on the neocortex via orthonormal bases of the Laplace-Beltrami operator. IEEE Trans Med Imaging. 2006; 25(10):1296-306. DOI: 10.1109/tmi.2006.882143. View

15.

Qiu A, Miller M . Multi-structure network shape analysis via normal surface momentum maps. Neuroimage. 2008; 42(4):1430-8. DOI: 10.1016/j.neuroimage.2008.04.257. View

16.

Parent M, Parent A . Single-axon tracing study of corticostriatal projections arising from primary motor cortex in primates. J Comp Neurol. 2006; 496(2):202-13. DOI: 10.1002/cne.20925. View

17.

Gazzaley A, Cooney J, McEvoy K, Knight R, DEsposito M . Top-down enhancement and suppression of the magnitude and speed of neural activity. J Cogn Neurosci. 2005; 17(3):507-17. DOI: 10.1162/0898929053279522. View

18.

Rizzolatti G, Fogassi L, Gallese V . Neurophysiological mechanisms underlying the understanding and imitation of action. Nat Rev Neurosci. 2001; 2(9):661-70. DOI: 10.1038/35090060. View

19.

Singer H . Neurobiological issues in Tourette syndrome. Brain Dev. 1994; 16(5):353-64. DOI: 10.1016/0387-7604(94)90122-8. View

20.

Aylward E, Reiss A, Reader M, Singer H, Brown J, Denckla M . Basal ganglia volumes in children with attention-deficit hyperactivity disorder. J Child Neurol. 1996; 11(2):112-5. DOI: 10.1177/088307389601100210. View