Gastric Tumours in Hereditary Cancer Syndromes: Clinical Features, Molecular Biology and Strategies for Prevention

Overview

Journal Clin Transl Oncol

Specialty Oncology

Date 2011 Aug 26

PMID 21865131

Citations 14

Authors

Maria Sereno

Cristina Aguayo

Carmen Guillen Ponce

Cesar Gomez-Raposo

Francisco Zambrana

Miriam Gomez-Lopez

Enrique Casado

Affiliations

Soon will be listed here.

Abstract

Gastric cancer is the major cause of cancer-related deaths worldwide. The majority of them are classified as sporadic, whereas the remaining 10% exhibit familial clustering. Hereditary diffuse gastric cancer (HDGC) syndrome is the most important condition that leads to hereditary gastric cancer. However, other hereditary cancer syndromes, such as hereditary non-polyposis colorectal cancer, familial adenomatous polyposis, Peutz-Jeghers syndrome, Li-Fraumeni syndrome and hereditary breast and ovarian cancer, entail a higher risk compared to the general population for developing this kind of neoplasia. In this review, we describe briefly the most important aspects related to clinical features, molecular biology and strategies for prevention in hereditary gastric associated to different cancer syndromes.

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References

Domizio P, Talbot I, Spigelman A, Williams C, Phillips R . Upper gastrointestinal pathology in familial adenomatous polyposis: results from a prospective study of 102 patients. J Clin Pathol. 1990; 43(9):738-43. PMC: 502752. DOI: 10.1136/jcp.43.9.738. View

Gylling A, Abdel-Rahman W, Juhola M, Nuorva K, Hautala E, Jarvinen H . Is gastric cancer part of the tumour spectrum of hereditary non-polyposis colorectal cancer? A molecular genetic study. Gut. 2007; 56(7):926-33. PMC: 1994336. DOI: 10.1136/gut.2006.114876. View

Petersen G, Slack J, Nakamura Y . Screening guidelines and premorbid diagnosis of familial adenomatous polyposis using linkage. Gastroenterology. 1991; 100(6):1658-64. DOI: 10.1016/0016-5085(91)90666-9. View

Giardiello F, Hylind L, Trimbath J, Hamilton S, Romans K, Cruz-Correa M . Oral contraceptives and polyp regression in familial adenomatous polyposis. Gastroenterology. 2005; 128(4):1077-80. DOI: 10.1053/j.gastro.2004.10.010. View

Caldas C, Carneiro F, Lynch H, Yokota J, Wiesner G, Powell S . Familial gastric cancer: overview and guidelines for management. J Med Genet. 1999; 36(12):873-80. PMC: 1734270. View

Easton D, Steele L, Fields P, Ormiston W, Averill D, Daly P . Cancer risks in two large breast cancer families linked to BRCA2 on chromosome 13q12-13. Am J Hum Genet. 1997; 61(1):120-8. PMC: 1715847. DOI: 10.1086/513891. View

Hebbard P, Macmillan A, Huntsman D, Kaurah P, Carneiro F, Wen X . Prophylactic total gastrectomy (PTG) for hereditary diffuse gastric cancer (HDGC): the Newfoundland experience with 23 patients. Ann Surg Oncol. 2009; 16(7):1890-5. DOI: 10.1245/s10434-009-0471-z. View

Bianchi L, Burke C, Bennett A, Lopez R, Hasson H, Church J . Fundic gland polyp dysplasia is common in familial adenomatous polyposis. Clin Gastroenterol Hepatol. 2008; 6(2):180-5. DOI: 10.1016/j.cgh.2007.11.018. View

Winawer S, Fletcher R, Rex D, Bond J, Burt R, Ferrucci J . Colorectal cancer screening and surveillance: clinical guidelines and rationale-Update based on new evidence. Gastroenterology. 2003; 124(2):544-60. DOI: 10.1053/gast.2003.50044. View

10.

Abraham S, Nobukawa B, Giardiello F, Hamilton S, Wu T . Fundic gland polyps in familial adenomatous polyposis: neoplasms with frequent somatic adenomatous polyposis coli gene alterations. Am J Pathol. 2000; 157(3):747-54. PMC: 1885693. DOI: 10.1016/S0002-9440(10)64588-9. View

11.

Birch J, Alston R, McNally R, Evans D, Kelsey A, Harris M . Relative frequency and morphology of cancers in carriers of germline TP53 mutations. Oncogene. 2001; 20(34):4621-8. DOI: 10.1038/sj.onc.1204621. View

12.

Spigelman A, Williams C, Talbot I, Domizio P, Phillips R . Upper gastrointestinal cancer in patients with familial adenomatous polyposis. Lancet. 1989; 2(8666):783-5. DOI: 10.1016/s0140-6736(89)90840-4. View

13.

Birch J, Hartley A, Tricker K, Prosser J, Condie A, Kelsey A . Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families. Cancer Res. 1994; 54(5):1298-304. View

14.

Defago M, Higa A, CAMPRA J, Paradelo M, Uehara A, Torres Mazzucchi M . Carcinoma in situ arising in a gastric hamartomatous polyp in a patient with Peutz-Jeghers syndrome. Endoscopy. 1996; 28(2):267. DOI: 10.1055/s-2007-1005447. View

15.

Konishi F, Wyse N, Muto T, Sawada T, Morioka Y, Sugimura H . Peutz-Jeghers polyposis associated with carcinoma of the digestive organs. Report of three cases and review of the literature. Dis Colon Rectum. 1987; 30(10):790-9. DOI: 10.1007/BF02554629. View

16.

Lewis F, Mellinger J, Hayashi A, Lorelli D, Monaghan K, Carneiro F . Prophylactic total gastrectomy for familial gastric cancer. Surgery. 2001; 130(4):612-7; discussion 617-9. DOI: 10.1067/msy.2001.117099. View

17.

Lao-Sirieix P, Caldas C, Fitzgerald R . Genetic predisposition to gastro-oesophageal cancer. Curr Opin Genet Dev. 2010; 20(3):210-7. DOI: 10.1016/j.gde.2010.03.002. View

18.

Guilford P, Hopkins J, Harraway J, McLeod M, McLeod N, Harawira P . E-cadherin germline mutations in familial gastric cancer. Nature. 1998; 392(6674):402-5. DOI: 10.1038/32918. View

19.

Debinski H, Spigelman A, Hatfield A, Williams C, Phillips R . Upper intestinal surveillance in familial adenomatous polyposis. Eur J Cancer. 1995; 31A(7-8):1149-53. DOI: 10.1016/0959-8049(95)00171-e. View

20.

Charlton A, Blair V, Shaw D, Parry S, Guilford P, Martin I . Hereditary diffuse gastric cancer: predominance of multiple foci of signet ring cell carcinoma in distal stomach and transitional zone. Gut. 2004; 53(6):814-20. PMC: 1774074. DOI: 10.1136/gut.2002.010447. View