Familial Gastric Cancers

Overview

Journal Oncologist

Publisher Oxford University Press

Specialty Oncology

Date 2015 Oct 2

PMID 26424758

Citations 23

Authors

Namrata Setia

Jeffrey W Clark

Dan G Duda

Theodore S Hong

Eunice L Kwak

John T Mullen

Gregory Y Lauwers

Affiliations

Soon will be listed here.

Abstract

Although the majority of gastric carcinomas are sporadic, approximately 10% show familial aggregation, and a hereditary cause is determined in 1%-3% cases. Of these, hereditary diffuse gastric cancer is the most recognized predisposition syndrome. Although rare, the less commonly known syndromes also confer a markedly increased risk for development of gastric cancer. Identification and characterization of these syndromes require a multidisciplinary effort involving oncologists, surgeons, genetic counselors, biologists, and pathologists. This article reviews the molecular genetics, clinical and pathologic features, surveillance guidelines, and preventive measures of common and less common hereditary gastric cancer predisposition syndromes.

Citing Articles

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