Free Radicals and Ischemic Tissue Injury

Overview

Journal Trends Pharmacol Sci

Specialty Pharmacology

Date 1990 Apr 1

PMID 2185587

Citations 27

Authors

S W Werns

B R Lucchesi

Affiliations

Soon will be listed here.

Abstract

There is growing evidence that reperfusion of ischemic organs is associated with the formation of free radicals that exacerbate the ischemic injury. Free radicals may damage viable tissue via the peroxidation of lipids and oxidation of protein sulfhydryl groups, leading to perturbations of membrane permeability and enzyme function. Steven Werns and Benedict Lucchesi discuss evidence that activated neutrophils are an important source of free radicals after cardiac and intestinal ischemia, and assess the strategies that have been investigated as ways of alleviating damage caused by free radicals during ischemia-reperfusion.

Citing Articles

MiR-153 is Involved in Testicular Ischemia/Reperfusion Injury by Directly Targeting FOXO3 and Regulating Spermatogonia Pyroptosis.

Ning J, Wang J, Xu L, Li H Mol Biotechnol. 2024; .

PMID: 38664304 DOI: 10.1007/s12033-024-01156-z.

Exploring the Chemical Constituents, Antioxidant, Xanthine Oxidase and COX Inhibitory Activity of Commonly Grown Wild in Saudi Arabia.

Shadid K, Shakya A, Naik R, Al-Qaisi T, Oriquat G, Atoom A Molecules. 2023; 28(5).

PMID: 36903563 PMC: 10004785. DOI: 10.3390/molecules28052321.

Vitamin D3 Prevents the Deleterious Effects of Testicular Torsion on Testis by Targeting miRNA-145 and ADAM17: In Silico and In Vivo Study.

Mohamed D, Abou-Bakr D, Ezzat S, Abd El-Kareem H, Abo Nahas H, Saad H Pharmaceuticals (Basel). 2021; 14(12).

PMID: 34959623 PMC: 8703569. DOI: 10.3390/ph14121222.

Carvacrol treatment opens Kir6.2 ATP-dependent potassium channels and prevents apoptosis on rat testis following ischemia-reperfusion injury model.

Balci C, Firat T, Acar N, Kukner A Rom J Morphol Embryol. 2021; 62(1):179-190.

PMID: 34609420 PMC: 8597367. DOI: 10.47162/RJME.62.1.17.

Fatty Acid Analysis, Chemical Constituents, Biological Activity and Pesticide Residues Screening in Jordanian Propolis.

Naik R, Shakya A, Oriquat G, Katekhaye S, Paradkar A, Fearnley H Molecules. 2021; 26(16).

PMID: 34443664 PMC: 8398578. DOI: 10.3390/molecules26165076.