Dual Effects of Caffeoyl-amino Acidyl-hydroxamic Acid As an Antioxidant and Depigmenting Agent

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2011 Aug 16

PMID 21840713

Citations 7

Authors

Seon-Yeong Kwak

Song Lee

Hye-Ryung Choi

Kyung-Chan Park

Yoon-Sik Lee

Affiliations

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Abstract

Anti-aging and depigmentation have both been an important subject of study for skin disease and the cosmetic industry. Caffeic acid (CA) has shown synergistically enhanced antioxidant activity when conjugated with amino acids. Hydroxamic acid (NHOH) is a well-known metal chelator, potentially having both tyrosinase inhibitory activity and free radical scavenging activity. We prepared caffeoyl-amino acidyl-hydroxamic acid (CA-Xaa-NHOH) and found that caffeoyl-prolyl-hydroxamic acid (CA-Pro-NHOH) contained excellent antioxidant activity and tyrosinase inhibitory activity by various bioassay systems. Also, CA-Pro-NHOH showed mild melanogenesis inhibitory activity in Mel-Ab cells.

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