Plasma Insulin, Serum Lipids and Lipoproteins in Gall Stone Disease in Non-insulin Dependent Diabetic Subjects: a Case Control Study

Overview

Journal Gut

Specialty Gastroenterology

Date 1990 Mar 1

PMID 2182400

Citations 16

Authors

M Laakso

M Suhonen

R Julkunen

K Pyorala

Affiliations

Soon will be listed here.

Abstract

Fasting insulin, lipids and lipoproteins were measured in 22 middle aged female non-insulin dependent diabetics with gall stone disease (cases) and in 22 non-insulin dependent diabetics without gall stone disease (controls). The groups were matched for sex, age, obesity, and fasting glucose concentrations. No differences were observed between the cases and controls in duration of diabetes, glycated haemoglobin A1, alcohol intake, smoking, use of cardiovascular drugs or a history of myocardial infarction. Diabetics with gall stone disease had higher fasting insulin concentrations (p less than 0.5), lower total (p less than 0.01) and low density lipoprotein cholesterol (p less than 0.01) and high density lipoprotein cholesterol (not statistically significant) concentrations than diabetics without gall stone disease. These changes in insulin, lipids and lipoproteins are similar to reported changes in non-diabetic subjects with gall stone disease. Therefore, they are characteristic for gall stone disease and not as such explanatory to an increased risk of gall stones in patients with non-insulin dependent diabetes.

Citing Articles

The association between diabetes and gallstones: a nationwide population-based cohort study.

Ratheesh R, Ulrich M, Ghozy S, Al-Jaboori M, Nayak S Prz Gastroenterol. 2023; 18(3):292-299.

PMID: 37937115 PMC: 10626383. DOI: 10.5114/pg.2023.131395.

Gallstone Ileus Decades after Cholecystectomy and Pylorus-Preserving Whipples.

Mugino M, Yabe T, Ashford B Case Rep Surg. 2020; 2020:8866254.

PMID: 33294247 PMC: 7718047. DOI: 10.1155/2020/8866254.

Association Between Type I and II Diabetes With Gallbladder Stone Disease.

Chen C, Lin C, Hsu C, Kao C Front Endocrinol (Lausanne). 2018; 9:720.

PMID: 30555418 PMC: 6281708. DOI: 10.3389/fendo.2018.00720.

Diabetes and the Pancreatobiliary Diseases.

Shafqet M, Sharzehi K Curr Treat Options Gastroenterol. 2017; 15(4):508-519.

PMID: 29079901 DOI: 10.1007/s11938-017-0163-x.

Prevalence of gallstone disease in patients with type 2 diabetes and the risk factors in North Indian population: a case control study.

Singh Sodhi J, Zargar S, Khateeb S, Showkat A, Javid G, Laway B Indian J Gastroenterol. 2014; 33(6):507-11.

PMID: 25283265 DOI: 10.1007/s12664-014-0502-y.

References

Friedman G, Kannel W, DAWBER T . The epidemiology of gallbladder disease: observations in the Framingham Study. J Chronic Dis. 1966; 19(3):273-92. DOI: 10.1016/0021-9681(66)90132-9. View

Kissebah A, Alfarsi S, Evans D, Adams P . Plasma low density lipoprotein transport kinetics in noninsulin-dependent diabetes mellitus. J Clin Invest. 1983; 71(3):655-67. PMC: 436915. DOI: 10.1172/jci110812. View

Cavallini A, Messa C, Mangini V, Argese V, Misciagna G, Giorgio I . Serum and bile lipids in young women with radiolucent gallstones. Am J Gastroenterol. 1987; 82(12):1279-82. View

Penttila I, Voutilainen E, Laitinen P, Juutilainen P . Comparison of different analytical and precipitation methods for direct estimation of serum high-density lipoprotein cholesterol. Scand J Clin Lab Invest. 1981; 41(4):353-60. DOI: 10.3109/00365518109092057. View

Ahlberg J . Serum lipid levels and hyperlipoproteinaemia in gallstone patients. Acta Chir Scand. 1979; 145(6):373-7. View

Bennion L, Grundy S . Risk factors for the development of cholelithiasis in man (second of two parts). N Engl J Med. 1978; 299(22):1221-7. DOI: 10.1056/NEJM197811302992205. View

Garnick M, BENNETT P, Langer T . Low density lipoprotein metabolism and lipoprotein cholesterol content in southwestern American Indians. J Lipid Res. 1979; 20(1):31-. View

Yang R, Arem R, Chan L . Gastrointestinal tract complications of diabetes mellitus. Pathophysiology and management. Arch Intern Med. 1984; 144(6):1251-6. View

Sampliner R, BENNETT P, Comess L, ROSE F, Burch T . Gallbladder disease in pima indians. Demonstration of high prevalence and early onset by cholecystography. N Engl J Med. 1970; 283(25):1358-64. DOI: 10.1056/NEJM197012172832502. View

10.

Laakso M, Ronnemaa T, Pyorala K, KALLIO V, Puukka P, Penttila I . Atherosclerotic vascular disease and its risk factors in non-insulin-dependent diabetic and nondiabetic subjects in Finland. Diabetes Care. 1988; 11(6):449-63. DOI: 10.2337/diacare.11.6.449. View

11.

van der LINDEN . Some biological traits in female gallstone-disease patients. A study of body build, parity and serum cholesterol level with a discussion of some problems of selection in observational hospital data. Acta Chir Scand Suppl. 1961; Suppl 269:1-94. View

12.

Petitti D, Friedman G, Klatsky A . Association of a history of gallbladder disease with a reduced concentration of high-density-lipoprotein cholesterol. N Engl J Med. 1981; 304(23):1396-8. DOI: 10.1056/NEJM198106043042305. View

13.

Laakso M, Pyorala K, Voutilainen E, Marniemi J . Plasma insulin and serum lipids and lipoproteins in middle-aged non-insulin-dependent diabetic and non-diabetic subjects. Am J Epidemiol. 1987; 125(4):611-21. DOI: 10.1093/oxfordjournals.aje.a114574. View

14.

Scragg R, Calvert G, Oliver J . Plasma lipids and insulin in gall stone disease: a case-control study. Br Med J (Clin Res Ed). 1984; 289(6444):521-5. PMC: 1442729. DOI: 10.1136/bmj.289.6444.521. View

15.

Mabee T, Meyer P, Denbesten L, Mason E . The mechanism of increased gallstone formation in obese human subjects. Surgery. 1976; 79(4):460-8. View

16.

Stout R, Balmer J, Henry R, Buchanan K . Plasma lipids and gastro-intestinal hormones in subjects with gallstones. Horm Metab Res. 1978; 10(4):357. DOI: 10.1055/s-0028-1095833. View

17.

HAVEL R, EDER H, Bragdon J . The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest. 1955; 34(9):1345-53. PMC: 438705. DOI: 10.1172/JCI103182. View

18.

Norton J, Smith L, Hamper E . Diabetes mellitus and gallstones with special reference to insulin assay. Am J Gastroenterol. 1968; 50(3):214-20. View

19.

Chait A, Bierman E, Albers J . Low-density lipoprotein receptor activity in cultured human skin fibroblasts. Mechanism of insulin-induced stimulation. J Clin Invest. 1979; 64(5):1309-19. PMC: 371278. DOI: 10.1172/JCI109587. View

20.

Grundy S, Metzger A, Adler R . Mechanisms of lithogenic bile formation in American Indian women with cholesterol gallstones. J Clin Invest. 1972; 51(12):3026-43. PMC: 332985. DOI: 10.1172/JCI107130. View