Inflammation in the Early Stages of Neurodegenerative Pathology

Overview

Journal J Neuroimmunol

Specialty Neurology

Date 2011 Aug 9

PMID 21820744

Citations 93

Authors

Preeti J Khandelwal

Alexander M Herman

Charbel E-H Moussa

Affiliations

Soon will be listed here.

Abstract

Inflammation is secondary to protein accumulation in neurodegenerative diseases, including Alzheimer's, Parkinson's and Amyotrophic Lateral Sclerosis. Emerging evidence indicate sustained inflammatory responses, involving microglia and astrocytes in animal models of neurodegeneration. It is unknown whether inflammation is beneficial or detrimental to disease progression and how inflammatory responses are induced within the CNS. Persistence of an inflammatory stimulus or failure to resolve sustained inflammation can result in pathology, thus, mechanisms that counteract inflammation are indispensable. Here we review studies on inflammation mediated by innate and adaptive immunity in the early stages of neurodegeneration and highlight important areas for future investigation.

Citing Articles

Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges.

Safiri S, Ghaffari Jolfayi A, Fazlollahi A, Morsali S, Sarkesh A, Daei Sorkhabi A Front Med (Lausanne). 2024; 11:1474043.

PMID: 39736972 PMC: 11682909. DOI: 10.3389/fmed.2024.1474043.

Investigating the protective properties of Panax ginseng and its constituents against biotoxins and metal toxicity: a mechanistic review.

Rameshrad M, Memariani Z, Naraki K, Hosseinzadeh H Naunyn Schmiedebergs Arch Pharmacol. 2024; 398(2):1215-1242.

PMID: 39287674 DOI: 10.1007/s00210-024-03410-2.

Outdoor air pollution and brain development in childhood and adolescence.

Herting M, Bottenhorn K, Cotter D Trends Neurosci. 2024; 47(8):593-607.

PMID: 39054161 PMC: 11324378. DOI: 10.1016/j.tins.2024.06.008.

Sleep-wake behavior and responses to sleep deprivation and immune challenge of protein kinase RNA-activated knockout mice.

Valencia-Sanchez S, Davis M, Martensen J, Hoeffer C, Link C, Opp M Brain Behav Immun. 2024; 121:74-86.

PMID: 39043346 PMC: 11563030. DOI: 10.1016/j.bbi.2024.07.027.

Delivery of CDNF by AAV-mediated gene transfer protects dopamine neurons and regulates ER stress and inflammation in an acute MPTP mouse model of Parkinson's disease.

Nam J, Richie C, Harvey B, Voutilainen M Sci Rep. 2024; 14(1):16487.

PMID: 39019902 PMC: 11254911. DOI: 10.1038/s41598-024-65735-5.

References

Simi A, Tsakiri N, Wang P, Rothwell N . Interleukin-1 and inflammatory neurodegeneration. Biochem Soc Trans. 2007; 35(Pt 5):1122-6. DOI: 10.1042/BST0351122. View

McCoy M, Tansey M . TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J Neuroinflammation. 2008; 5:45. PMC: 2577641. DOI: 10.1186/1742-2094-5-45. View

Kuhn D, Francescutti-Verbeem D, Thomas D . Dopamine quinones activate microglia and induce a neurotoxic gene expression profile: relationship to methamphetamine-induced nerve ending damage. Ann N Y Acad Sci. 2006; 1074:31-41. DOI: 10.1196/annals.1369.003. View

Gebicke-Haerter P . Microglia in neurodegeneration: molecular aspects. Microsc Res Tech. 2001; 54(1):47-58. DOI: 10.1002/jemt.1120. View

Huang Y, Erdmann N, Peng H, Zhao Y, Zheng J . The role of TNF related apoptosis-inducing ligand in neurodegenerative diseases. Cell Mol Immunol. 2005; 2(2):113-22. View

Ryan L, Peng H, Erichsen D, Huang Y, Persidsky Y, Zhou Y . TNF-related apoptosis-inducing ligand mediates human neuronal apoptosis: links to HIV-1-associated dementia. J Neuroimmunol. 2004; 148(1-2):127-39. DOI: 10.1016/j.jneuroim.2003.11.019. View

Griffith T, Wiley S, Kubin M, Sedger L, Maliszewski C, Fanger N . Monocyte-mediated tumoricidal activity via the tumor necrosis factor-related cytokine, TRAIL. J Exp Med. 1999; 189(8):1343-54. PMC: 2193036. DOI: 10.1084/jem.189.8.1343. View

Glezer I, Bittencourt J, Rivest S . Neuronal expression of Cd36, Cd44, and Cd83 antigen transcripts maps to distinct and specific murine brain circuits. J Comp Neurol. 2009; 517(6):906-24. DOI: 10.1002/cne.22185. View

Banerjee R, Mosley R, Reynolds A, Dhar A, Jackson-Lewis V, Gordon P . Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice. PLoS One. 2008; 3(7):e2740. PMC: 2481277. DOI: 10.1371/journal.pone.0002740. View

10.

Lu G, Janjic B, Janjic J, Whiteside T, Storkus W, Vujanovic N . Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related apoptosis-inducing ligand. J Immunol. 2002; 168(4):1831-9. DOI: 10.4049/jimmunol.168.4.1831. View

11.

Doi Y, Mizuno T, Maki Y, Jin S, Mizoguchi H, Ikeyama M . Microglia activated with the toll-like receptor 9 ligand CpG attenuate oligomeric amyloid {beta} neurotoxicity in in vitro and in vivo models of Alzheimer's disease. Am J Pathol. 2009; 175(5):2121-32. PMC: 2774075. DOI: 10.2353/ajpath.2009.090418. View

12.

Vargas M, Pehar M, Diaz-Amarilla P, Beckman J, Barbeito L . Transcriptional profile of primary astrocytes expressing ALS-linked mutant SOD1. J Neurosci Res. 2008; 86(16):3515-25. PMC: 4048747. DOI: 10.1002/jnr.21797. View

13.

Zipp F, Aktas O . The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases. Trends Neurosci. 2006; 29(9):518-27. DOI: 10.1016/j.tins.2006.07.006. View

14.

Tahara K, Kim H, Jin J, Maxwell J, Li L, Fukuchi K . Role of toll-like receptor signalling in Abeta uptake and clearance. Brain. 2006; 129(Pt 11):3006-19. PMC: 2445613. DOI: 10.1093/brain/awl249. View

15.

Fiala M, Liu P, Espinosa-Jeffrey A, Rosenthal M, Bernard G, Ringman J . Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. Proc Natl Acad Sci U S A. 2007; 104(31):12849-54. PMC: 1937555. DOI: 10.1073/pnas.0701267104. View

16.

Ray S, Britschgi M, Herbert C, Takeda-Uchimura Y, Boxer A, Blennow K . Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Nat Med. 2007; 13(11):1359-62. DOI: 10.1038/nm1653. View

17.

Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole G . Inflammation and Alzheimer's disease. Neurobiol Aging. 2000; 21(3):383-421. PMC: 3887148. DOI: 10.1016/s0197-4580(00)00124-x. View

18.

Liu Y, Hao W, Dawson A, Liu S, Fassbender K . Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2. J Biol Chem. 2008; 284(6):3691-9. DOI: 10.1074/jbc.M804446200. View

19.

Arizmendi J, Runswick M, Skehel J, Walker J . NADH: ubiquinone oxidoreductase from bovine heart mitochondria. A fourth nuclear encoded subunit with a homologue encoded in chloroplast genomes. FEBS Lett. 1992; 301(3):237-42. DOI: 10.1016/0014-5793(92)80248-f. View

20.

Dawson T, Dawson V . Molecular pathways of neurodegeneration in Parkinson's disease. Science. 2003; 302(5646):819-22. DOI: 10.1126/science.1087753. View