[Serum and Synovial Adiponectin, Resistin, and Visfatin Levels in Rheumatoid Arthritis Patients. Relation to Disease Activity]

Overview

Journal Z Rheumatol

Publisher Springer

Specialty Rheumatology

Date 2011 Jul 27

PMID 21789720

Citations 14

Authors

E A M Alkady

H M Ahmed

L Tag

M A Abdou

Affiliations

Soon will be listed here.

Abstract

Background: Recent data provided evidence on the implication of the adipocytokines adiponectin, visfatin, and resistin in inflammation, immune response, and tissue destruction and revealed several links between them and arthritis.

Aim Of The Study: The purpose of this study was to assess the levels of adiponectin, visfatin, and resistin in serum and synovial fluid of patients with rheumatoid arthritis (RA) and their relationship with disease activity.

Subjects And Methods: A total of 70 female patients with RA and 30 age- and sex-matched healthy controls were enrolled. The clinical activity of RA patients was assessed according to the 28 joint count Disease Activity Score and patients were classified into two groups: 39 patients with active disease (group A) and 31 patients in remission (group B). Synovial fluid was obtained by arthrocentesis of the affected knee joints from 39 patients with active disease. Serum adiponectin, visfatin, and resistin concentrations were measured in RA patients and controls, while a specific enzyme-linked immunosorbent assay was used to measure the synovial concentrations of adiponectin, visfatin, and resistin in the group of patients with active RA.

Results: Serum levels of adiponectin and visfatin were significantly higher in all RA patients and patients with active disease compared to the control group and patients in remission. No significant difference was observed in the resistin level between patients and controls. Serum and synovial adiponectin and visfatin were positively correlated with DAS28-ESR in RA patients with active disease.

Conclusion: Our data demonstrated that adiponectin and visfatin are related to disease activity in RA patients and might be involved in the progression of RA. The English full-text version of this article is available at SpringerLink (under "Supplemental").

Citing Articles

Adipokines in Rheumatoid Arthritis: Emerging Biomarkers and Therapeutic Targets.

Bilski J, Schramm-Luc A, Szczepanik M, Mazur-Bialy A, Bonior J, Luc K Biomedicines. 2023; 11(11).

PMID: 38001998 PMC: 10669400. DOI: 10.3390/biomedicines11112998.

Inflammation-Involved Proteins in Blood Serum of Cataract Patients-A Preliminary Study.

Sutkowy P, Lesiewska H, Wozniak A, Malukiewicz G Biomedicines. 2023; 11(10).

PMID: 37892980 PMC: 10604040. DOI: 10.3390/biomedicines11102607.

No Causal Association Between Adiponectin and the Risk of Rheumatoid Arthritis: A Mendelian Randomization Study.

Chen H, Mi S, Zhu J, Jin W, Li Y, Wang T Front Genet. 2021; 12:670282.

PMID: 34630505 PMC: 8498100. DOI: 10.3389/fgene.2021.670282.

Adiponectin Deregulation in Systemic Autoimmune Rheumatic Diseases.

Brezovec N, Perdan-Pirkmajer K, cucnik S, Sodin-Semrl S, Varga J, Lakota K Int J Mol Sci. 2021; 22(8).

PMID: 33920997 PMC: 8071452. DOI: 10.3390/ijms22084095.

The Adipokine Network in Rheumatic Joint Diseases.

Carrion M, Frommer K, Perez-Garcia S, Muller-Ladner U, Gomariz R, Neumann E Int J Mol Sci. 2019; 20(17).

PMID: 31443349 PMC: 6747092. DOI: 10.3390/ijms20174091.

References

Coppack S . Pro-inflammatory cytokines and adipose tissue. Proc Nutr Soc. 2001; 60(3):349-56. DOI: 10.1079/pns2001110. View

Palmer G, Gabay C . A role for leptin in rheumatic diseases?. Ann Rheum Dis. 2003; 62(10):913-5. PMC: 1754337. DOI: 10.1136/ard.62.10.913. View

Otero M, Lago R, Gomez R, Lago F, Dieguez C, Gomez-Reino J . Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Ann Rheum Dis. 2006; 65(9):1198-201. PMC: 1798289. DOI: 10.1136/ard.2005.046540. View

Filkova M, Liskova M, Hulejova H, Haluzik M, Gatterova J, Pavelkova A . Increased serum adiponectin levels in female patients with erosive compared with non-erosive osteoarthritis. Ann Rheum Dis. 2009; 68(2):295-6. DOI: 10.1136/ard.2008.095737. View

Senolt L, Housa D, Vernerova Z, Jirasek T, Svobodova R, Veigl D . Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum. Ann Rheum Dis. 2006; 66(4):458-63. PMC: 1856051. DOI: 10.1136/ard.2006.054734. View

Dumond H, Presle N, Terlain B, Mainard D, Loeuille D, Netter P . Evidence for a key role of leptin in osteoarthritis. Arthritis Rheum. 2003; 48(11):3118-29. DOI: 10.1002/art.11303. View

Fantuzzi G . Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol. 2005; 115(5):911-9. DOI: 10.1016/j.jaci.2005.02.023. View

Schaffler A, Ehling A, Neumann E, Herfarth H, Tarner I, Scholmerich J . Adipocytokines in synovial fluid. JAMA. 2003; 290(13):1709-10. DOI: 10.1001/jama.290.13.1709-c. View

Forsblad dElia H, Pullerits R, Carlsten H, Bokarewa M . Resistin in serum is associated with higher levels of IL-1Ra in post-menopausal women with rheumatoid arthritis. Rheumatology (Oxford). 2008; 47(7):1082-7. DOI: 10.1093/rheumatology/ken187. View

10.

Nowell M, Richards P, Fielding C, Ognjanovic S, Topley N, Williams A . Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis. Arthritis Rheum. 2006; 54(7):2084-95. DOI: 10.1002/art.21942. View

11.

Steppan C, Bailey S, Bhat S, Brown E, Banerjee R, Wright C . The hormone resistin links obesity to diabetes. Nature. 2001; 409(6818):307-12. DOI: 10.1038/35053000. View

12.

Tang C, Chiu Y, Tan T, Yang R, Fu W . Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway. J Immunol. 2007; 179(8):5483-92. DOI: 10.4049/jimmunol.179.8.5483. View

13.

Lago F, Dieguez C, Gomez-Reino J, Gualillo O . Adipokines as emerging mediators of immune response and inflammation. Nat Clin Pract Rheumatol. 2007; 3(12):716-24. DOI: 10.1038/ncprheum0674. View

14.

Bokarewa M, Nagaev I, Dahlberg L, Smith U, Tarkowski A . Resistin, an adipokine with potent proinflammatory properties. J Immunol. 2005; 174(9):5789-95. DOI: 10.4049/jimmunol.174.9.5789. View

15.

Koerner A, Kratzsch J, Kiess W . Adipocytokines: leptin--the classical, resistin--the controversical, adiponectin--the promising, and more to come. Best Pract Res Clin Endocrinol Metab. 2005; 19(4):525-46. DOI: 10.1016/j.beem.2005.07.008. View

16.

Kitahara K, Kusunoki N, Kakiuchi T, Suguro T, Kawai S . Adiponectin stimulates IL-8 production by rheumatoid synovial fibroblasts. Biochem Biophys Res Commun. 2008; 378(2):218-23. DOI: 10.1016/j.bbrc.2008.11.017. View

17.

Ehling A, Schaffler A, Herfarth H, Tarner I, Anders S, Distler O . The potential of adiponectin in driving arthritis. J Immunol. 2006; 176(7):4468-78. DOI: 10.4049/jimmunol.176.7.4468. View

18.

Moschen A, Kaser A, Enrich B, Mosheimer B, Theurl M, Niederegger H . Visfatin, an adipocytokine with proinflammatory and immunomodulating properties. J Immunol. 2007; 178(3):1748-58. DOI: 10.4049/jimmunol.178.3.1748. View

19.

Brentano F, Schorr O, Ospelt C, Stanczyk J, Gay R, Gay S . Pre-B cell colony-enhancing factor/visfatin, a new marker of inflammation in rheumatoid arthritis with proinflammatory and matrix-degrading activities. Arthritis Rheum. 2007; 56(9):2829-39. DOI: 10.1002/art.22833. View

20.

Arnett F, Edworthy S, Bloch D, McShane D, Fries J, Cooper N . The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988; 31(3):315-24. DOI: 10.1002/art.1780310302. View