A Tripartite HIV-1 Tat-env-rev Fusion Protein

Overview

Journal EMBO J

Specialties Biotechnology
Molecular Biology

Date 1990 Mar 1

PMID 2178928

Citations 32

Authors

J Salfeld

H G Gottlinger

R A Sia

R E Park

J G Sodroski

W A Haseltine

Affiliations

Soon will be listed here.

Abstract

A 26 kd protein reactive with antiserum to the transactivator tat of the Human Immunodeficiency Virus Type 1 (HIV-1) has been detected in virus producing cells. The 26 kd protein is shown to be a tripartite fusion protein including coding sequences of the tat, envelope (env) and regulator of virion expression (rev) genes. Fusion of these coding sequences occurs by use of a previously undescribed exon within env. This 26 kd protein, designated tnv, has tat but no rev activity detectable with the assay used. The existence of other less abundant tat and rev related proteins in HIV-1 producing cells is also noted.

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