TDP-43 Functions and Pathogenic Mechanisms Implicated in TDP-43 Proteinopathies

Overview

Journal Trends Mol Med

Specialties General Medicine
Molecular Biology

Date 2011 Jul 26

PMID 21783422

Citations 136

Authors

Todd J Cohen

Virginia M Y Lee

John Q Trojanowski

Affiliations

Soon will be listed here.

Abstract

Given the critical role for TDP-43 in diverse neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP), there has been a recent surge in efforts to understand the normal functions of TDP-43 and the molecular basis of dysregulation that occurs in TDP-43 proteinopathies. Here, we highlight recent findings examining TDP-43 molecular functions with particular emphasis on stress-mediated regulation of TDP-43 localization, putative downstream TDP-43 target genes and RNAs, as well as TDP-43 interacting proteins, all of which represent viable points of therapeutic intervention for ALS, FTLD-TDP and related proteinopathies. Finally, we review current mouse models of TDP-43 and discuss their similarities and potential relevance to human TDP-43 proteinopathies including ALS and FTLD-TDP.

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