Regulation of Microtubule Dynamics by TOG-domain Proteins XMAP215/Dis1 and CLASP

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2011 Jul 26

PMID 21782439

Citations 139

Authors

Jawdat Al-Bassam

Fred Chang

Affiliations

Soon will be listed here.

Abstract

The molecular mechanisms by which microtubule-associated proteins (MAPs) regulate the dynamic properties of microtubules (MTs) are still poorly understood. We review recent advances in our understanding of two conserved families of MAPs, the XMAP215/Dis1 and CLASP family of proteins. In vivo and in vitro studies show that XMAP215 proteins act as microtubule polymerases at MT plus ends to accelerate MT assembly, and CLASP proteins promote MT rescue and suppress MT catastrophe events. These are structurally related proteins that use conserved TOG domains to recruit tubulin dimers to MTs. We discuss models for how these proteins might use these individual tubulin dimers to regulate dynamic behavior of MT plus ends.

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