Generating Receptive Endometrium in Asherman's Syndrome

Overview

Journal J Hum Reprod Sci

Date 2011 Jul 21

PMID 21772741

Citations 32

Authors

Caroline E Gargett

David L Healy

Affiliations

Soon will be listed here.

Abstract

Intrauterine administration of bone marrow stem/progenitor cells to a woman with thin endometrium refractory to estrogen stimulation regenerated her endometrium sufficiently to support a pregnancy. Or was it local endometrial damage induced by concurrent curettage that stimulated endogenous endometrial stem/progenitor cells into action? Or both?

Citing Articles

Human Endometrial Pericytes: A Comprehensive Overview of Their Physiological Functions and Implications in Uterine Disorders.

Tang Y, Frisendahl C, Piltonen T, Arffman R, Lalitkumar P, Gemzell-Danielsson K Cells. 2024; 13(17.

PMID: 39273080 PMC: 11394273. DOI: 10.3390/cells13171510.

Endometrial organoids: a reservoir of functional mitochondria for uterine repair.

Hwang S, Lee D, Lee G, Ahn J, Lee Y, Koo H Theranostics. 2024; 14(3):954-972.

PMID: 38250040 PMC: 10797286. DOI: 10.7150/thno.90538.

Endometrial and placental stem cells in successful and pathological pregnancies.

Giri J, Modi D J Assist Reprod Genet. 2023; 40(7):1509-1522.

PMID: 37338750 PMC: 10352206. DOI: 10.1007/s10815-023-02856-2.

Improvement of vaginal probiotics Lactobacillus crispatus on intrauterine adhesion in mice model and in clinical practice.

Wu F, Kong Y, Chen W, Liang D, Xiao Q, Hu L BMC Microbiol. 2023; 23(1):78.

PMID: 36949381 PMC: 10032012. DOI: 10.1186/s12866-023-02823-y.

Autologous bone marrow-derived nucleated cell (aBMNC) transplantation improves endometrial function in patients with refractory Asherman's syndrome or with thin and dysfunctional endometrium.

Arikan G, Turan V, Kurekeken M, Goksoy H, Dogusan Z J Assist Reprod Genet. 2023; 40(5):1163-1171.

PMID: 36662355 PMC: 10239402. DOI: 10.1007/s10815-023-02727-w.

References

Salamonsen L . Tissue injury and repair in the female human reproductive tract. Reproduction. 2003; 125(3):301-11. DOI: 10.1530/rep.0.1250301. View

Hyun I, Lindvall O, Ahrlund-Richter L, Cattaneo E, Cavazzana-Calvo M, Cossu G . New ISSCR guidelines underscore major principles for responsible translational stem cell research. Cell Stem Cell. 2008; 3(6):607-9. DOI: 10.1016/j.stem.2008.11.009. View

Halfon S, Abramov N, Grinblat B, Ginis I . Markers distinguishing mesenchymal stem cells from fibroblasts are downregulated with passaging. Stem Cells Dev. 2010; 20(1):53-66. DOI: 10.1089/scd.2010.0040. View

Barash A, Dekel N, Fieldust S, Segal I, Schechtman E, Granot I . Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization. Fertil Steril. 2003; 79(6):1317-22. DOI: 10.1016/s0015-0282(03)00345-5. View

Chan R, Gargett C . Identification of label-retaining cells in mouse endometrium. Stem Cells. 2006; 24(6):1529-38. DOI: 10.1634/stemcells.2005-0411. View

Alaiti M, Ishikawa M, Costa M . Bone marrow and circulating stem/progenitor cells for regenerative cardiovascular therapy. Transl Res. 2010; 156(3):112-29. DOI: 10.1016/j.trsl.2010.06.008. View

Prockop D . Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms. Mol Ther. 2009; 17(6):939-46. PMC: 2835176. DOI: 10.1038/mt.2009.62. View

Barash A, Granot I, Fieldust S, Or Y . Successful pregnancy and delivery of a healthy baby after endometrial biopsy treatment in an in vitro fertilization patient with severe Asherman syndrome. Fertil Steril. 2009; 91(5):1956.e1-3. DOI: 10.1016/j.fertnstert.2009.01.128. View

Schenker J, Margalioth E . Intrauterine adhesions: an updated appraisal. Fertil Steril. 1982; 37(5):593-610. DOI: 10.1016/s0015-0282(16)46268-0. View

10.

Caplan A . Why are MSCs therapeutic? New data: new insight. J Pathol. 2008; 217(2):318-24. PMC: 8793150. DOI: 10.1002/path.2469. View

11.

Yu D, Wong Y, Cheong Y, Xia E, Li T . Asherman syndrome--one century later. Fertil Steril. 2008; 89(4):759-79. DOI: 10.1016/j.fertnstert.2008.02.096. View

12.

Li R, Hao G . Local injury to the endometrium: its effect on implantation. Curr Opin Obstet Gynecol. 2009; 21(3):236-9. DOI: 10.1097/GCO.0b013e32832a0654. View

13.

Kaituu-Lino T, Morison N, Salamonsen L . Estrogen is not essential for full endometrial restoration after breakdown: lessons from a mouse model. Endocrinology. 2007; 148(10):5105-11. DOI: 10.1210/en.2007-0716. View

14.

Schwab K, Gargett C . Co-expression of two perivascular cell markers isolates mesenchymal stem-like cells from human endometrium. Hum Reprod. 2007; 22(11):2903-11. DOI: 10.1093/humrep/dem265. View

15.

Lindvall O, Hyun I . Medical innovation versus stem cell tourism. Science. 2009; 324(5935):1664-5. DOI: 10.1126/science.1171749. View

16.

Nagori C, Panchal S, Patel H . Endometrial regeneration using autologous adult stem cells followed by conception by in vitro fertilization in a patient of severe Asherman's syndrome. J Hum Reprod Sci. 2011; 4(1):43-8. PMC: 3136069. DOI: 10.4103/0974-1208.82360. View

17.

Gargett C, Masuda H . Adult stem cells in the endometrium. Mol Hum Reprod. 2010; 16(11):818-34. DOI: 10.1093/molehr/gaq061. View

18.

Taylor H . Endometrial cells derived from donor stem cells in bone marrow transplant recipients. JAMA. 2004; 292(1):81-5. DOI: 10.1001/jama.292.1.81. View

19.

Lo S, Ramsay P, Pierson R, Manconi F, Munro M, Fraser I . Endometrial thickness measured by ultrasound scan in women with uterine outlet obstruction due to intrauterine or upper cervical adhesions. Hum Reprod. 2007; 23(2):306-9. DOI: 10.1093/humrep/dem393. View

20.

Du H, Taylor H . Contribution of bone marrow-derived stem cells to endometrium and endometriosis. Stem Cells. 2007; 25(8):2082-6. DOI: 10.1634/stemcells.2006-0828. View