Manipulation of Host Membranes by Bacterial Effectors

Overview

Journal Nat Rev Microbiol

Specialties Infectious Diseases
Microbiology

Date 2011 Jul 19

PMID 21765451

Citations 71

Authors

Hyeilin Ham

Anju Sreelatha

Kim Orth

Affiliations

Soon will be listed here.

Abstract

Bacterial pathogens interact with host membranes to trigger a wide range of cellular processes during the course of infection. These processes include alterations to the dynamics between the plasma membrane and the actin cytoskeleton, and subversion of the membrane-associated pathways involved in vesicle trafficking. Such changes facilitate the entry and replication of the pathogen, and prevent its phagocytosis and degradation. In this Review, we describe the manipulation of host membranes by numerous bacterial effectors that target phosphoinositide metabolism, GTPase signalling and autophagy.

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