Alcohol Exposure in Utero Leads to Enhanced Prepubertal Mammary Development and Alterations in Mammary IGF and Estradiol Systems

Overview

Journal Horm Cancer

Date 2011 Jul 16

PMID 21761112

Citations 7

Authors

Tiffany A Polanco

Catina Crismale-Gann

Wendie S Cohick

Affiliations

Soon will be listed here.

Abstract

Exposure to alcohol during fetal development increases susceptibility to mammary cancer in adult rats. This study determined if early changes in mammary morphology and the insulin-like growth factor (IGF)/estradiol axis are involved in the mechanisms that underlie this increased susceptibility. Pregnant Sprague-Dawley rats were fed a liquid diet containing 6.7% ethanol (alcohol), an isocaloric liquid diet (pair-fed), or rat chow ad libitum from days 11 to 21 of gestation. At birth, female pups were cross-fostered to ad libitum-fed control dams. Offspring were euthanized at postnatal days (PND) 20, 40, or 80. Animals were injected with BrdU before euthanasia, then mammary glands, serum, and livers were collected. Mammary glands from animals exposed to alcohol in utero displayed increased epithelial cell proliferation and aromatase expression at PND 20 and 40. Mammary IGF-I mRNA was higher in alcohol-exposed animals relative to controls at PND 20, while mammary IGFBP-5 mRNA was lower in this group at PND 40. Hepatic IGF-I mRNA expression was increased at all time points in alcohol-exposed animals, however, circulating IGF-I levels were not altered. These data indicate that alcohol exposure in utero may advance mammary development via the IGF and estradiol systems, which could contribute to increased susceptibility to mammary cancer later in life.

Citing Articles

Fetal Alcohol Exposure Alters Mammary Epithelial Cell Subpopulations and Promotes Tumorigenesis.

Saboya M, Jetzt A, Datar K, Cohick W Alcohol Clin Exp Res. 2020; 44(4):831-843.

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Prenatal alcohol exposure increases the susceptibility to develop aggressive prolactinomas in the pituitary gland.

Jabbar S, Reuhl K, Sarkar D Sci Rep. 2018; 8(1):7720.

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TRIENNIAL LACTATION SYMPOSIUM/BOLFA: Dietary regulation of allometric ductal growth in the mammary glands.

Berryhill G, Trott J, Derpinghaus A, Hovey R J Anim Sci. 2018; 95(12):5664-5674.

PMID: 29293798 PMC: 6292269. DOI: 10.2527/jas2017.1901.

Tumor Phenotype and Gene Expression During Early Mammary Tumor Development in Offspring Exposed to Alcohol In Utero.

Crismale-Gann C, Stires H, Katz T, Cohick W Alcohol Clin Exp Res. 2016; 40(8):1679-90.

PMID: 27373230 PMC: 4961575. DOI: 10.1111/acer.13139.

Alcohol exposure in utero perturbs retinoid homeostasis in adult rats.

Kim Y, Zuccaro M, Zhang C, Sarkar D, Quadro L Hepatobiliary Surg Nutr. 2015; 4(4):268-77.

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