TRIENNIAL LACTATION SYMPOSIUM/BOLFA: Dietary Regulation of Allometric Ductal Growth in the Mammary Glands

Overview

Journal J Anim Sci

Date 2018 Jan 3

PMID 29293798

Citations 3

Authors

G E Berryhill

J F Trott

A L Derpinghaus

R C Hovey

Affiliations

Soon will be listed here.

Abstract

Although mammary gland growth and development in females is a lifelong process, it builds on isometric and allometric phases of mammary growth to establish a complex ductal network before and during puberty. Only then can other phases of branching and alveologenesis, differentiation, lactation, and involution proceed. Although the ductal network of various species differs in its histomorphology, all glands undergo a common phase of allometric growth when the mammary ducts penetrate into the supporting stromal microenvironment. Perhaps not surprisingly, different aspects of diet and nutrition can influence this allometric growth, either directly or indirectly. In this review, we outline some of the fundamental aspects of how allometric ductal growth in the mammary glands of various species is influenced by diet and nutrition and identify opportunities and questions for future investigation.

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References

Tsubura A, Yoshizawa K, Uehara N, Yuri T, Matsuoka Y . Multistep mouse mammary tumorigenesis through pre-neoplasia to neoplasia and acquisition of metastatic potential. Med Mol Morphol. 2007; 40(1):9-17. DOI: 10.1007/s00795-006-0351-6. View

Sejrsen K, Purup S, Vestergaard M, Foldager J . High body weight gain and reduced bovine mammary growth: physiological basis and implications for milk yield potential. Domest Anim Endocrinol. 2000; 19(2):93-104. DOI: 10.1016/s0739-7240(00)00070-9. View

Ip C, Dong Y, Thompson H, Bauman D, Ip M . Control of rat mammary epithelium proliferation by conjugated linoleic acid. Nutr Cancer. 2002; 39(2):233-8. DOI: 10.1207/S15327914nc392_12. View

Schennink A, Trott J, Berryhill G, Donovan C, Manjarin R, VanKlompenberg M . Alcohol intake stimulates epithelial proliferation in an authentic model of the human breast. Reprod Toxicol. 2014; 54:93-100. DOI: 10.1016/j.reprotox.2014.10.020. View

Johnson M, Kenney N, Stoica A, Hilakivi-Clarke L, Singh B, Chepko G . Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland. Nat Med. 2003; 9(8):1081-4. DOI: 10.1038/nm902. View

Lohakare J, Sudekum K, Pattanaik A . Nutrition-induced Changes of Growth from Birth to First Calving and Its Impact on Mammary Development and First-lactation Milk Yield in Dairy Heifers: A Review. Asian-Australas J Anim Sci. 2014; 25(9):1338-50. PMC: 4092940. DOI: 10.5713/ajas.2012.12282. View

Veltmaat J, Ramsdell A, Sterneck E . Positional variations in mammary gland development and cancer. J Mammary Gland Biol Neoplasia. 2013; 18(2):179-88. PMC: 3691492. DOI: 10.1007/s10911-013-9287-3. View

Buric D, Brisken C . Analysis of Mammary Gland Phenotypes by Transplantation of the Genetically Marked Mammary Epithelium. Methods Mol Biol. 2016; 1501:115-129. DOI: 10.1007/978-1-4939-6475-8_4. View

WELSCH C, OConnor D . Influence of the type of dietary fat on developmental growth of the mammary gland in immature and mature female BALB/c mice. Cancer Res. 1989; 49(21):5999-6007. View

10.

Horigan K, Trott J, Barndollar A, Scudder J, Blauwiekel R, Hovey R . Hormone interactions confer specific proliferative and histomorphogenic responses in the porcine mammary gland. Domest Anim Endocrinol. 2009; 37(2):124-38. DOI: 10.1016/j.domaniend.2009.04.002. View

11.

Singletary K, McNary M . Effect of moderate ethanol consumption on mammary gland structural development and DNA synthesis in the female rat. Alcohol. 1992; 9(2):95-101. DOI: 10.1016/0741-8329(92)90018-6. View

12.

Tucker H, Parsons C, Ellis S, Rhoads M, Akers R . Tamoxifen impairs prepubertal mammary development and alters expression of estrogen receptor α (ESR1) and progesterone receptors (PGR). Domest Anim Endocrinol. 2015; 54:95-105. DOI: 10.1016/j.domaniend.2015.10.002. View

13.

Rowson-Hodel A, Manjarin R, Trott J, Cardiff R, Borowsky A, Hovey R . Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo. BMC Cancer. 2015; 15:562. PMC: 4520266. DOI: 10.1186/s12885-015-1572-7. View

14.

Rowson A, Daniels K, Ellis S, Hovey R . Growth and development of the mammary glands of livestock: a veritable barnyard of opportunities. Semin Cell Dev Biol. 2012; 23(5):557-66. DOI: 10.1016/j.semcdb.2012.03.018. View

15.

Mallepell S, Krust A, Chambon P, Brisken C . Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland. Proc Natl Acad Sci U S A. 2006; 103(7):2196-201. PMC: 1413744. DOI: 10.1073/pnas.0510974103. View

16.

Proia D, Kuperwasser C . Reconstruction of human mammary tissues in a mouse model. Nat Protoc. 2007; 1(1):206-14. DOI: 10.1038/nprot.2006.31. View

17.

Russo J, Hu Y, Silva I, Russo I . Cancer risk related to mammary gland structure and development. Microsc Res Tech. 2001; 52(2):204-23. DOI: 10.1002/1097-0029(20010115)52:2<204::AID-JEMT1006>3.0.CO;2-F. View

18.

Ellis S, McFadden T, Akers R . Prepuberal ovine mammary development is unaffected by ovariectomy. Domest Anim Endocrinol. 1998; 15(4):217-25. DOI: 10.1016/s0739-7240(98)00009-5. View

19.

Parsa S, Ramasamy S, De Langhe S, Gupte V, Haigh J, Medina D . Terminal end bud maintenance in mammary gland is dependent upon FGFR2b signaling. Dev Biol. 2008; 317(1):121-31. DOI: 10.1016/j.ydbio.2008.02.014. View

20.

Cleary M . Impact of obesity on development and progression of mammary tumors in preclinical models of breast cancer. J Mammary Gland Biol Neoplasia. 2013; 18(3-4):333-43. PMC: 4296516. DOI: 10.1007/s10911-013-9300-x. View