Cellular and Molecular Choreography of Neutrophil Recruitment to Sites of Sterile Inflammation

Overview

Journal J Mol Med (Berl)

Specialty General Medicine

Date 2011 Jul 14

PMID 21751029

Citations 38

Authors

Braedon McDonald

Paul Kubes

Affiliations

Soon will be listed here.

Abstract

Liberation of damage-associated molecular patterns (DAMPs) following tissue injury and necrotic cell death leads to the induction of sterile inflammation. A hallmark of acute inflammation is the recruitment of neutrophils to injured tissues. This review focuses on the journey of neutrophils to sites of sterile inflammation and the cellular and molecular mechanisms that choreograph this complex voyage. We review the pathway of leukocyte recruitment, with emphasis on recent additions to our understanding of intravascular neutrophil migration. The contributions of various tissue-resident sentinel cell populations to the detection of danger signals (DAMPs) and coordination of neutrophil recruitment and migration are discussed. In addition, we highlight recent data on the control of neutrophil chemotaxis towards sites of sterile inflammation, including new insight into the temporal and spatial regulation of chemoattractant guidance signals that direct cell migration. Given that inappropriate neutrophilic inflammation is a cornerstone in the pathogenesis of many diseases, a complete understanding of the choreography of neutrophil recruitment to sites of sterile inflammation may uncover new avenues for therapeutic interventions to treat inflammatory pathologies.

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References

Stewart C, Stuart L, Wilkinson K, van Gils J, Deng J, Halle A . CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol. 2009; 11(2):155-61. PMC: 2809046. DOI: 10.1038/ni.1836. View

Carp H . Mitochondrial N-formylmethionyl proteins as chemoattractants for neutrophils. J Exp Med. 1982; 155(1):264-75. PMC: 2186576. DOI: 10.1084/jem.155.1.264. View

Foxman E, Campbell J, Butcher E . Multistep navigation and the combinatorial control of leukocyte chemotaxis. J Cell Biol. 1998; 139(5):1349-60. PMC: 2140208. DOI: 10.1083/jcb.139.5.1349. View

Carman C, Springer T . Trans-cellular migration: cell-cell contacts get intimate. Curr Opin Cell Biol. 2008; 20(5):533-40. PMC: 2811962. DOI: 10.1016/j.ceb.2008.05.007. View

Borregaard N . Neutrophils, from marrow to microbes. Immunity. 2010; 33(5):657-70. DOI: 10.1016/j.immuni.2010.11.011. View

Mizgerd J, Kubo H, Kutkoski G, Bhagwan S, Scharffetter-Kochanek K, Beaudet A . Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice. J Exp Med. 1997; 186(8):1357-64. PMC: 2199087. DOI: 10.1084/jem.186.8.1357. View

Soehnlein O, Lindbom L . Phagocyte partnership during the onset and resolution of inflammation. Nat Rev Immunol. 2010; 10(6):427-39. DOI: 10.1038/nri2779. View

Boilard E, Nigrovic P, Larabee K, Watts G, Coblyn J, Weinblatt M . Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science. 2010; 327(5965):580-3. PMC: 2927861. DOI: 10.1126/science.1181928. View

Taylor K, Trowbridge J, Rudisill J, Termeer C, Simon J, Gallo R . Hyaluronan fragments stimulate endothelial recognition of injury through TLR4. J Biol Chem. 2004; 279(17):17079-84. DOI: 10.1074/jbc.M310859200. View

10.

McDonald B, McAvoy E, Lam F, Gill V, de la Motte C, Savani R . Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids. J Exp Med. 2008; 205(4):915-27. PMC: 2292228. DOI: 10.1084/jem.20071765. View

11.

Kool M, Soullie T, van Nimwegen M, Willart M, Muskens F, Jung S . Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J Exp Med. 2008; 205(4):869-82. PMC: 2292225. DOI: 10.1084/jem.20071087. View

12.

Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J . Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006; 440(7081):237-41. DOI: 10.1038/nature04516. View

13.

Lindemann S, Tolley N, Dixon D, McIntyre T, Prescott S, Zimmerman G . Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis. J Cell Biol. 2001; 154(3):485-90. PMC: 2196422. DOI: 10.1083/jcb.200105058. View

14.

Li H, Ambade A, Re F . Cutting edge: Necrosis activates the NLRP3 inflammasome. J Immunol. 2009; 183(3):1528-32. DOI: 10.4049/jimmunol.0901080. View

15.

Wong C, Heit B, Kubes P . Molecular regulators of leucocyte chemotaxis during inflammation. Cardiovasc Res. 2010; 86(2):183-91. DOI: 10.1093/cvr/cvq040. View

16.

Viola A, Luster A . Chemokines and their receptors: drug targets in immunity and inflammation. Annu Rev Pharmacol Toxicol. 2007; 48:171-97. DOI: 10.1146/annurev.pharmtox.48.121806.154841. View

17.

Hofmann M, Drury S, Fu C, Qu W, Taguchi A, Lu Y . RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999; 97(7):889-901. DOI: 10.1016/s0092-8674(00)80801-6. View

18.

Huo Y, Schober A, Forlow S, Smith D, Hyman M, Jung S . Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med. 2002; 9(1):61-7. DOI: 10.1038/nm810. View

19.

Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y . Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med. 2005; 11(11):1173-9. DOI: 10.1038/nm1315. View

20.

Nahrendorf M, Swirski F, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo J . The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med. 2007; 204(12):3037-47. PMC: 2118517. DOI: 10.1084/jem.20070885. View