Ruthenium-catalyzed Oxidative C-H Bond Alkenylations in Water: Expedient Synthesis of Annulated Lactones

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2011 Jul 14

PMID 21749083

Citations 15

Authors

Lutz Ackermann

Jola Pospech

Affiliations

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Abstract

Ruthenium-catalyzed cross-dehydrogenative C-H bond alkenylations occurred efficiently in environmentally benign water, which was exploited for an oxidative phthalide synthesis with ample scope. Mechanistic studies provided strong evidence for the oxidative alkenylation to proceed by an irreversible C-H bond metalation via acetate assistance.

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