Proinvasion Metastasis Drivers in Early-stage Melanoma Are Oncogenes

Overview

Journal Cancer Cell

Publisher Cell Press

Specialty Oncology

Date 2011 Jul 12

PMID 21741599

Citations 83

Authors

Kenneth L Scott

Cristina Nogueira

Timothy P Heffernan

Remco van Doorn

Sabin Dhakal

Jason A Hanna

Chengyin Min

Mariela Jaskelioff

Yonghong Xiao

Chang-Jiun Wu

Lisa A Cameron

Samuel R Perry

Rhamy Zeid

Tamar Feinberg

Minjung Kim

George Vande Woude

Scott R Granter

Marcus Bosenberg

Gerald C Chu

Ronald A DePinho

David L Rimm

Lynda Chin

Affiliations

Soon will be listed here.

Abstract

Clinical and genomic evidence suggests that the metastatic potential of a primary tumor may be dictated by prometastatic events that have additional oncogenic capability. To test this "deterministic" hypothesis, we adopted a comparative oncogenomics-guided function-based strategy involving: (1) comparison of global transcriptomes of two genetically engineered mouse models with contrasting metastatic potential, (2) genomic and transcriptomic profiles of human melanoma, (3) functional genetic screen for enhancers of cell invasion, and (4) evidence of expression selection in human melanoma tissues. This integrated effort identified six genes that are potently proinvasive and oncogenic. Furthermore, we show that one such gene, ACP5, confers spontaneous metastasis in vivo, engages a key pathway governing metastasis, and is prognostic in human primary melanomas.

Citing Articles

M1 macrophage-derived exosomal microRNA-29c-3p suppresses aggressiveness of melanoma cells via ENPP2.

An B, Shin C, Kwon J, Tran N, Kim A, Jeong H Cancer Cell Int. 2024; 24(1):325.

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Fascin-1 Promotes Cell Metastasis through Epithelial-Mesenchymal Transition in Canine Mammary Tumor Cell Lines.

Wang X, Zhou Y, Wang L, Haseeb A, Li H, Zheng X Vet Sci. 2024; 11(6).

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Association of ACP5 with the tumor immune microenvironment and its role in cell proliferation and metastasis in pancreatic cancer.

Shen J, Shi M, Song A, Ming Y, Zhu X, Ruan Y Am J Transl Res. 2023; 15(11):6437-6450.

PMID: 38074824 PMC: 10703664.

Blockade of the pro-fibrotic reaction mediated by the miR-143/-145 cluster enhances the responses to targeted therapy in melanoma.

Diazzi S, Baeri A, Fassy J, Lecacheur M, Marin-Bejar O, Girard C EMBO Mol Med. 2022; 14(3):e15295.

PMID: 35156321 PMC: 8899916. DOI: 10.15252/emmm.202115295.

A functional genomic approach to actionable gene fusions for precision oncology.

Li J, Lu H, Ng P, Pantazi A, Ip C, Jeong K Sci Adv. 2022; 8(6):eabm2382.

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