Mapping the Networks for Pluripotency

Overview

Journal Philos Trans R Soc Lond B Biol Sci

Specialty Biology

Date 2011 Jul 6

PMID 21727129

Citations 11

Authors

Kun Xue

Jia-Hui Ng

Huck-Hui Ng

Affiliations

Soon will be listed here.

Abstract

There has been an immense interest in embryonic stem cells owing to their pluripotent property, which refers to the ability to differentiate into all cell types of an embryo. In the maintenance of this pluripotent nature, transcription factors play essential roles, and signalling pathways also act to sustain the undifferentiated state. Recent studies have unravelled multiple forms of interconnection and crosstalk between these two regulatory aspects of pluripotency. With the discovery of epiblast stem cells, there is an emerging concept that different pluripotent states could exist, and knowledge of both transcriptional networks and signalling pathways has been vital in dissecting the properties of these different states. Similar to classical reprogramming methodologies, various combinations of transcription factor transduction and the modulation of intracellular signalling have enabled the interconversion between pluripotent states. These studies provide an insight into the defining characteristics as well as the plasticity of pluripotent cells.

Citing Articles

Locus-Specific Isolation of the Chromatin Identifies Regulators Relevant to Pluripotency of Mouse Embryonic Stem Cells and Reprogramming of Somatic Cells.

Burramsetty A, Nishimura K, Kishimoto T, Hamzah M, Kuno A, Fukuda A Int J Mol Sci. 2022; 23(23).

PMID: 36499566 PMC: 9740452. DOI: 10.3390/ijms232315242.

FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency.

Mossahebi-Mohammadi M, Quan M, Zhang J, Li X Front Cell Dev Biol. 2020; 8:79.

PMID: 32133359 PMC: 7040165. DOI: 10.3389/fcell.2020.00079.

Modeling Mammalian Commitment to the Neural Lineage Using Embryos and Embryonic Stem Cells.

Shparberg R, Glover H, Morris M Front Physiol. 2019; 10:705.

PMID: 31354503 PMC: 6637848. DOI: 10.3389/fphys.2019.00705.

Two decades of embryonic stem cells: a historical overview.

Eguizabal C, Aran B, Chuva de Sousa Lopes S, Geens M, Heindryckx B, Panula S Hum Reprod Open. 2019; 2019(1):hoy024.

PMID: 30895264 PMC: 6396646. DOI: 10.1093/hropen/hoy024.

Posttranscriptional control of the stem cell and neurogenic programs by the nonsense-mediated RNA decay pathway.

Lou C, Shao A, Shum E, Espinoza J, Huang L, Karam R Cell Rep. 2014; 6(4):748-64.

PMID: 24529710 PMC: 3962089. DOI: 10.1016/j.celrep.2014.01.028.

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