The Coupling of Pathways and Processes Through Shared Components

Overview

Journal BMC Syst Biol

Publisher Biomed Central

Specialty Biology

Date 2011 Jul 1

PMID 21714894

Citations 4

Authors

Daniel D Seaton

J Krishnan

Affiliations

Soon will be listed here.

Abstract

Background: The coupling of pathways and processes through shared components is being increasingly recognised as a common theme which occurs in many cell signalling contexts, in which it plays highly non-trivial roles.

Results: In this paper we develop a basic modelling and systems framework in a general setting for understanding the coupling of processes and pathways through shared components. Our modelling framework starts with the interaction of two components with a common third component and includes production and degradation of all these components. We analyze the signal processing in our model to elucidate different aspects of the coupling. We show how different kinds of responses, including "ultrasensitive" and adaptive responses, may occur in this setting. We then build on the basic model structure and examine the effects of additional control regulation, switch-like signal processing, and spatial signalling. In the process, we identify a way in which allosteric regulation may contribute to signalling specificity, and how competitive effects may allow an enzyme to robustly coordinate and time the activation of parallel pathways.

Conclusions: We have developed and analyzed a common systems platform for examining the effects of coupling of processes through shared components. This can be the basis for subsequent expansion and understanding the many biologically observed variations on this common theme.

Citing Articles

A unified approach to dissecting biphasic responses in cell signaling.

Ramesh V, Krishnan J Elife. 2023; 13.

PMID: 38054655 PMC: 10928513. DOI: 10.7554/eLife.86520.

Spatial Control of Biochemical Modification Cascades and Pathways.

Alam-Nazki A, Krishnan J Biophys J. 2015; 108(12):2912-24.

PMID: 26083931 PMC: 4472220. DOI: 10.1016/j.bpj.2015.05.012.

Biphasic responses in multi-site phosphorylation systems.

Suwanmajo T, Krishnan J J R Soc Interface. 2013; 10(89):20130742.

PMID: 24108693 PMC: 3808552. DOI: 10.1098/rsif.2013.0742.

Covalent modification cycles through the spatial prism.

Alam-Nazki A, Krishnan J Biophys J. 2013; 105(7):1720-31.

PMID: 24094413 PMC: 3822675. DOI: 10.1016/j.bpj.2013.06.050.

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