» Articles » PMID: 12714060

Enzymes with Extra Talents: Moonlighting Functions and Catalytic Promiscuity

Overview
Publisher Elsevier
Specialty Biochemistry
Date 2003 Apr 26
PMID 12714060
Citations 145
Authors
Affiliations
Soon will be listed here.
Abstract

Recent studies of moonlighting functions and catalytic promiscuity provide insights into the structural and mechanistic bases of these phenomena. Moonlighting proteins that are highlighted include gephyrin, the Neurospora crassa tyrosyl tRNA synthetase, phosphoglucose isomerase, and cytochrome c. New insights into catalytic promiscuity are provided by studies of aminoglycoside kinase (3') type IIIa, tetrachlorohydroquinone dehalogenase, and aldolase antibody 38C2.

Citing Articles

Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation.

Martinez M, Petit J, Leyva A, Sogues A, Megrian D, Rodriguez A Nat Microbiol. 2023; 8(10):1896-1910.

PMID: 37679597 PMC: 10522489. DOI: 10.1038/s41564-023-01473-0.


Nuclear PTEN Regulates Thymidylate Biosynthesis in Human Prostate Cancer Cell Lines.

Loh Z, Wang M, Wan C, Asara J, Ji Z, Chen M Metabolites. 2023; 13(8).

PMID: 37623882 PMC: 10456368. DOI: 10.3390/metabo13080939.


Paracatalytic induction: Subverting specificity in hedgehog protein autoprocessing with small molecules.

Ciulla D, Xu Z, Pezzullo J, Dranchak P, Wang C, Giner J Methods Enzymol. 2023; 685:1-41.

PMID: 37245899 PMC: 10294009. DOI: 10.1016/bs.mie.2023.03.001.


Moonlighting enzymes: when cellular context defines specificity.

Gupta M, Uversky V Cell Mol Life Sci. 2023; 80(5):130.

PMID: 37093283 PMC: 11073002. DOI: 10.1007/s00018-023-04781-0.


Functional molecular evolution of a GTP sensing kinase: PI5P4Kβ.

Takeuchi K, Senda M, Ikeda Y, Okuwaki K, Fukuzawa K, Nakagawa S FEBS J. 2023; 290(18):4419-4428.

PMID: 36856076 PMC: 10471773. DOI: 10.1111/febs.16763.