Preliminary Study of Letrozole Use for Improving Spermatogenesis in Non-obstructive Azoospermia Patients with Normal Serum FSH

Overview

Journal Asian J Androl

Specialty Urology

Date 2011 Jun 28

PMID 21706040

Citations 13

Authors

Giorgio Cavallini

Giovanni Beretta

Giulio Biagiotti

Affiliations

Soon will be listed here.

Abstract

We investigated whether letrozole (2.5 mg day(-1)) improves sperm count in non-obstructive azoospermia (NOA) patients. Four men were included in this study, and they had folliculo-stimulating hormone and other hormone levels within the normal range and no varicoceles or chromosomal aberrations. These four patients were administered letrozole for 3 months. Sperm count, testicular volume, gonadotropin, testosterone (T) and estradiol (E2) blood levels were assessed before, during and 1 week after the suspension of treatment. All patients showed spermatozoa in their ejaculate, increased gonadotropin and T levels and lower E2 levels (P<0.05 in all cases), when letrozole was administered. This suggests that letrozole treatment might improve sperm count in an NOA sub-population; however, more studies, including the proper controls, are needed to confirm its efficacy.

Citing Articles

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