Prevalence of Antibody Against Non-A, Non-B Hepatitis Virus in Japanese Patients with Hepatocellular Carcinoma

Overview

Journal Jpn J Cancer Res

Specialty Oncology

Date 1990 Jun 1

PMID 2169469

Citations 25

Authors

S Ohkoshi

H Kojima

H Tawaraya

T Miyajima

T Kamimura

H Asakura

A Satoh

S Hirose

M Hijikata

N Kato

Affiliations

Soon will be listed here.

Abstract

Antibodies against a possible causative agent of non-A, non-B hepatitis, hepatitis C virus (HCV), in Japanese patients with hepatocellular carcinoma were analyzed using the enzyme-linked immunosorbent assay (ELISA) system from Ortho Diagnostic Systems, Japan. Fifty of 58 cases of hepatitis B virus surface antigen (HBsAg)-negative hepatocellular carcinoma were positive for the antibody (86%) and 8 of 42 cases of HBsAg-positive hepatocellular carcinoma were positive (19%). Among patients with HBsAg-negative hepatocellular carcinoma, the prevalence of the antibody was greater among those who had received a blood transfusion (97%) than among those with no history of transfusion (70%). Only 3 of 54 patients with cancers other than hepatocellular carcinoma were found to be antibody-positive (5.6%) and all three patients had a history of blood transfusion. These results show a close relationship between the presence of anti-HCV antibody and HBsAg-negative hepatocellular carcinoma in Japan.

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