Efflux Pumps of the Resistance-nodulation-division Family: a Perspective of Their Structure, Function, and Regulation in Gram-negative Bacteria

Overview

Journal Adv Enzymol Relat Areas Mol Biol

Specialties Biochemistry
Molecular Biology

Date 2011 Jun 23

PMID 21692368

Citations 25

Authors

Mathew D Routh

Yaramah Zalucki

Chih-Chia Su

Qijing Zhang

William M Shafer

Edward W Yu

Affiliations

Soon will be listed here.

Citing Articles

Computational Evaluation of Fusarium nygamai Compounds as AcrD Efflux Pump Protein Inhibitors of Salmonella Typhimurium.

Garrido-Palazuelos L, Aguirre-Sanchez J, Sandoval-Gonzalez M, Mukhtar M, Guerra-Meza O, Ahmed-Khan H Mol Biotechnol. 2024; .

PMID: 39709333 DOI: 10.1007/s12033-024-01329-w.

Drug Binding to BamA Targets Its Lateral Gate.

Kuo K, Liu J, Pavlova A, Gumbart J J Phys Chem B. 2023; 127(34):7509-7517.

PMID: 37587651 PMC: 10476194. DOI: 10.1021/acs.jpcb.3c04501.

Periplasmic biomineralization for semi-artificial photosynthesis.

Lin Y, Shi J, Feng W, Yue J, Luo Y, Chen S Sci Adv. 2023; 9(29):eadg5858.

PMID: 37478187 PMC: 10361601. DOI: 10.1126/sciadv.adg5858.

Comparative genomics reveals the emergence of copper resistance in a non-pigmented Xanthomonas pathogen of grapevine.

Rana R, Jaiswal G, Bansal K, Patil P Environ Microbiol Rep. 2023; 15(6):716-726.

PMID: 37254648 PMC: 10667641. DOI: 10.1111/1758-2229.13164.

Repeated Emergence of Variant TetR Family Regulator, FarR, and Increased Resistance to Antimicrobial Unsaturated Fatty Acid among Clonal Complex 5 Methicillin-Resistant Staphylococcus aureus.

Bonn C, Rafiqullah I, Crawford J, Qian Y, Guthrie J, Matuszewska M Antimicrob Agents Chemother. 2023; 67(3):e0074922.

PMID: 36744906 PMC: 10019231. DOI: 10.1128/aac.00749-22.

References

Cagliero C, Mouline C, Payot S, Cloeckaert A . Involvement of the CmeABC efflux pump in the macrolide resistance of Campylobacter coli. J Antimicrob Chemother. 2005; 56(5):948-50. DOI: 10.1093/jac/dki292. View

Morita Y, Kodama K, Shiota S, Mine T, Kataoka A, Mizushima T . NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli. Antimicrob Agents Chemother. 1998; 42(7):1778-82. PMC: 105682. DOI: 10.1128/AAC.42.7.1778. View

Tzeng Y, Datta A, Ambrose K, Lo M, Davies J, Carlson R . The MisR/MisS two-component regulatory system influences inner core structure and immunotype of lipooligosaccharide in Neisseria meningitidis. J Biol Chem. 2004; 279(33):35053-62. DOI: 10.1074/jbc.M401433200. View

Elkins C, Mullis L . Mammalian steroid hormones are substrates for the major RND- and MFS-type tripartite multidrug efflux pumps of Escherichia coli. J Bacteriol. 2006; 188(3):1191-5. PMC: 1347360. DOI: 10.1128/JB.188.3.1191-1195.2006. View

Koronakis V, Sharff A, Koronakis E, Luisi B, Hughes C . Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export. Nature. 2000; 405(6789):914-9. DOI: 10.1038/35016007. View

Cagliero C, Mouline C, Cloeckaert A, Payot S . Synergy between efflux pump CmeABC and modifications in ribosomal proteins L4 and L22 in conferring macrolide resistance in Campylobacter jejuni and Campylobacter coli. Antimicrob Agents Chemother. 2006; 50(11):3893-6. PMC: 1635205. DOI: 10.1128/AAC.00616-06. View

Akama H, Kanemaki M, Yoshimura M, Tsukihara T, Kashiwagi T, Yoneyama H . Crystal structure of the drug discharge outer membrane protein, OprM, of Pseudomonas aeruginosa: dual modes of membrane anchoring and occluded cavity end. J Biol Chem. 2004; 279(51):52816-9. DOI: 10.1074/jbc.C400445200. View

Gibreel A, Taylor D . Macrolide resistance in Campylobacter jejuni and Campylobacter coli. J Antimicrob Chemother. 2006; 58(2):243-55. DOI: 10.1093/jac/dkl210. View

Schumacher M, Miller M, Grkovic S, Brown M, Skurray R, Brennan R . Structural mechanisms of QacR induction and multidrug recognition. Science. 2001; 294(5549):2158-63. DOI: 10.1126/science.1066020. View

10.

Su C, Nikaido H, Yu E . Ligand-transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay. FEBS Lett. 2007; 581(25):4972-6. PMC: 2254335. DOI: 10.1016/j.febslet.2007.09.035. View

11.

Hooper D . Mechanisms of action and resistance of older and newer fluoroquinolones. Clin Infect Dis. 2000; 31 Suppl 2:S24-8. DOI: 10.1086/314056. View

12.

Loftin I, Franke S, Roberts S, Weichsel A, Heroux A, Montfort W . A novel copper-binding fold for the periplasmic copper resistance protein CusF. Biochemistry. 2005; 44(31):10533-40. DOI: 10.1021/bi050827b. View

13.

Piddock L . Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin Microbiol Rev. 2006; 19(2):382-402. PMC: 1471989. DOI: 10.1128/CMR.19.2.382-402.2006. View

14.

Veal W, Shafer W . Identification of a cell envelope protein (MtrF) involved in hydrophobic antimicrobial resistance in Neisseria gonorrhoeae. J Antimicrob Chemother. 2002; 51(1):27-37. DOI: 10.1093/jac/dkg031. View

15.

Warner D, Shafer W, Jerse A . Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance and in vivo fitness. Mol Microbiol. 2008; 70(2):462-78. PMC: 2602950. DOI: 10.1111/j.1365-2958.2008.06424.x. View

16.

Paulsen I, Skurray R, Tam R, Saier Jr M, Turner R, Weiner J . The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs. Mol Microbiol. 1996; 19(6):1167-75. DOI: 10.1111/j.1365-2958.1996.tb02462.x. View

17.

Hoffmann K, Williams D, Shafer W, Brennan R . Characterization of the multiple transferable resistance repressor, MtrR, from Neisseria gonorrhoeae. J Bacteriol. 2005; 187(14):5008-12. PMC: 1169513. DOI: 10.1128/JB.187.14.5008-5012.2005. View

18.

Bratu S, Landman D, George A, Salvani J, Quale J . Correlation of the expression of acrB and the regulatory genes marA, soxS and ramA with antimicrobial resistance in clinical isolates of Klebsiella pneumoniae endemic to New York City. J Antimicrob Chemother. 2009; 64(2):278-83. PMC: 2707265. DOI: 10.1093/jac/dkp186. View

19.

Aires J, Nikaido H . Aminoglycosides are captured from both periplasm and cytoplasm by the AcrD multidrug efflux transporter of Escherichia coli. J Bacteriol. 2005; 187(6):1923-9. PMC: 1064028. DOI: 10.1128/JB.187.6.1923-1929.2005. View

20.

Franke S, Grass G, Nies D . The product of the ybdE gene of the Escherichia coli chromosome is involved in detoxification of silver ions. Microbiology (Reading). 2001; 147(Pt 4):965-972. DOI: 10.1099/00221287-147-4-965. View