Beyond Immediate Hypersensitivity: Evolving Roles for IgE Antibodies in Immune Homeostasis and Allergic Diseases

Overview

Journal Immunol Rev

Specialties Allergy & Immunology
General Surgery

Date 2011 Jun 21

PMID 21682742

Citations 62

Authors

Oliver T Burton

Hans C Oettgen

Affiliations

Soon will be listed here.

Abstract

Immunoglobulin E (IgE) antibodies have long been recognized as the antigen-specific triggers of allergic reactions. This review briefly introduces the established functions of IgE in immediate hypersensitivity and then focuses on emerging evidence from our own investigations as well as those of others that IgE plays important roles in protective immunity against parasites and exerts regulatory influences in the expression of its own receptors, FcεRI and CD23, as well as controlling mast cell homeostasis. We provide an overview of the multifaceted ways in which IgE antibodies contribute to the pathology of food allergy and speculate regarding potential mechanisms of action of IgE blockade.

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