Oncogene-induced Senescence and Its Role in Tumor Suppression

Overview

Journal J Mammary Gland Biol Neoplasia

Date 2011 Jun 18

PMID 21681694

Citations 10

Authors

Jay P Reddy

Yi Li

Affiliations

Soon will be listed here.

Abstract

While senescence has been known for some time as an inevitable result of repeated DNA replication, oncogene-induced senescence (OIS) represents a relatively new phenomenon. OIS, like apoptosis, has emerged to represent a putative barrier to tumorigenesis in many tissues, including the breast. Here we discuss signals that initiate OIS, evidence for its role in tumor suppression, and mechanisms for its evasion in tumorigenesis.

Citing Articles

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