Senescence-messaging Secretome: SMS-ing Cellular Stress

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2009 Jan 10

PMID 19132009

Citations 466

Authors

Thomas Kuilman

Daniel S Peeper

Affiliations

Soon will be listed here.

Abstract

Oncogene-induced cellular senescence constitutes a strong anti-proliferative response, which can be set in motion following either oncogene activation or loss of tumour suppressor signalling. It serves to limit the expansion of early neoplastic cells and as such is a potent cancer-protective response to oncogenic events. Recently emerging evidence points to a crucial role in oncogene-induced cellular senescence for the 'senescence-messaging secretome' or SMS, setting the stage for cross-talk between senescent cells and their environment. How are such signals integrated into a coordinated response and what are the implications of this unexpected finding?

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